Parkinsons disease

Question 1

Describe PD (7)

Answer 1

Chronic PND in NS, 20-40yo 50-per 100k uk

Demylination process

Degeneration of dopaminergic in neurons in substantia niagra in the BSN

Proteins found in neurons of sufferers

SN sends neurons to strictum to release dopamine

Dec in neurons = dec ability for thalamus to produce dopamine

dec in movement and slow progression

Question 2

Describe symptoms of PD (6)

Answer 2

Bradykinesia (slow reduction in movement)

Tremors in spec locations

Limbs or chin area

Imbalanced movement

Risk: Age, history, mutation of glucoseribidose gene

Exposure to MPTP

Question 3

Diagnosis for PD (5)

Answer 3

No test only view symptoms

FMH or Physical examination

Refer to neurologist

Gene restriction suspected in elderly

use SPECT (Single photon emitted computed topography) used to rule out symptoms

Question 4

Treatment for PD (5)

Answer 4

Mild: Consume dopaminergic agent inc QOL

Physical + cognitive therapy

Moderate Pd: 100mg daily of levadopa dec symptoms

P+C therapy also recommended

LS Pd: Deep brain stimulations for tremours + for severe refractory fluctation dec symptoms, P+C