Osteoperosis

Question 1

Pathophysiology 6

Answer 1

disorder, red BM due to inc bone erosion greater than BF

red in bone strength + higher fracture

osteoclasts resorb bone matric and osteoblasts create new bone

imbalance causes OP, supply affects cavity repair

Remodelling controlled by cytokines

RANK2 prod by OB binds to OC to promote funciton

Question 2

Cause 4

Answer 2

vit d + test def

Abnormal thyroid functions

high level parathyroid functions

alcoholism, diabetes, liver d

Question 3

Symptoms 5

Answer 3

bone pain, anemia, renal failure

fractures

skeletal deformity

spontaneous HF

spinal kyphosis

Question 4

diagnosis 4

Answer 4

BAsed on fragility using t score <2.5

Measure density using x-ray absorpantry

ultra-s to measure bone strength

quantitive computed tomography - trabecular bone density

Question 5

treatment 3

Answer 5

goal to prevent fractures; exercise for strength and balance

calc + vid int, biphosphates for pharmocolgical therapy

no cure