Multiple sclerosis

Question 1

Describe MS (6)

Answer 1

Chronic neurological disorder that affects 20-40yo, 50per 100k uk

Demylination process in brain

Mistakenly rec myelin in neuron - attacks

IS attacks neurons by travelling through bv in brain

Breaches endothelial lining in PBB - attacks neuron

TC release cytokine, causes infl, attacks more t cells, continues = prog

Question 2

Cause of MS (7)

Answer 2

Unknown, factors inc chances

Vit d def

Disproportion women

4 types: RRMS - random attacks e.g vision / motor loss = progress greater

SPMS = constant progression rather than emitting

PPMS = COnstant progression over time

PRMS = random ISA= Prog

Question 3

Symptoms of MS (5)

Answer 3

Tremours

Dystharial (Speaking difficulty)

Involuntary eye movements

Maybe be painful

Muscle weakness or spasms

Question 4

How to diagnose MS (2)

Answer 4

MRI 2 detect white plaque in brain

Cerebral fluid with high AB conc shows high liklihood of MS

Question 5

How to manage symptoms (5)

Answer 5

No cure but treatments

Cortico steroids or cyclophasamide

Red AIA, slows prog

Plasmophorus can remove AB that breached

Immunosuppressant dec cytokine conc, red t cell, pherapy etc

Question 6

How to prevent MS

Answer 6

Inc vit D, no smoking, sleep and balanced diet