Parkinsons (2) Flashcards
What are characteristics of idiopathic Parkinson’s?
Early onset <50 years old
Tremor dominant or postural imbalance and gait disorder dominant
What are characteristics of secondary Parkinsonism?
External cause (drug induced, toxins, infectious, tumor, or trauma)
What are characteristics of atypical Parkinsonism (parkinson plus)?
Progressive supranuclear palsy
Corticobasilar degeneration
Multiple system atrophy
Dementia with Lewy body
What are some characteristics of progressive supranuclear palsy?
Eye movement abnormalities (loss of downward gaze)
Broad based gait, ataxic, and arms abduct
What are some characteristics of corticobasilar degeneration?
Apraxia
Cortical sensory loss
Myoclonus
What are some characteristics of multiple system atrophy?
Autonomic dysfunction
Abnormal postures
What are some characteristics of dementia with Lewy body?
Dementia and visual hallucinations
How do symptoms progress in atypical parkinsonism?
Faster
What are the risk factors of Parkinson’s?
Age > 60
Males
Positive family history (genetics)
What are prodromal markers of neurodegenerative process?
REM sleep behavior disorder
Depression
Autonomic dysfunction
What % is loss before a Parkinson’s diagnosis?
80%
What are the key symptoms of Parkinson’s?
Rigidity
Bradykinesia
Postural instability
Tremor
What can levodopa treatment lead to?
Dyskinesia (impairment of voluntary movement)
What is camptocormia dystonia?
Thoracolumbar flexion (due to overactive rec fem)
What is pisa syndrome?
Truncal dystonia (lateral trunk flexion)
What is feet dystonia?
Flexion of toes and inversion of ankle
What % of Parkinson’s patients report pain?
95%
76% interfering with daily life