Parkinsons Flashcards
What is the pathology of Parkinson’s disease
Not enough dopamine, imbalance between dopamine and acetylcholine
Is Parkinson’s insidious or does it have a sudden onset?
Insidious, progressive, chronic
What are the cardinal features of Parkinson’s
Resting tremor that can decrease with purposeful activity, muscle rigidity, Brady kinesia, postural instability
Does the resting tremor resolved with activity
Yes
Do tremors occur/start bilaterally or unilaterally
Starting unilaterally that spreads contralaterally over several years
What is muscle rigidity
Increased resistance to passive range of motion that is a jerking quality, also started unilaterally than spreads
What is Brady kinesia
Generalize slowness in movement, Can be described as a weakness, and coordination, and tiredness
What is the major cause of disability in Parkinson’s patients? Which symptom
Brady kinesia
What are some non-motor clinical manifestations of Parkinson’s that could be considered neuropsychiatric
Cognitive dysfunction, dementia, psychosis, hallucinations, mood disorders, or factory dysfunction, sleep disturbance,
Autonomic dysfunction including orthostasis constipation dysphasia diaphoresis urinary difficulties and sexual dysfunction.
Pain and sensory disorders including face abdomen genitals and joints.
What will a patient with Parkinson’s gait look like
Short shuffling gait
Micrographia
PD/OFS handwriting, writing is shrunken head tilted compared to normal handwriting
How to diagnose Parkinson’s
No specific diagnostic test, based on history and clinical features. Usually 2 to 3 signs of classic triad present. Ultimate confirmation would include a positive response to anti-parkinsonian drugs
Levodopa
Most effective drug for symptomatic Parkinson’s, most effective for Bradykinesia’s, lots of side effects, on and off phenomenon eventually occurs
Main drug therapy for Parkinson’s
Levodopa, dopamine agonist, anti-cholinergic. Anti-cholinergic would be used as a mono therapy, dopamine would be used as a mono therapy or combo medication.
What is the on off phenomenon?
Consequence of long-term levodopa. On equals mobile, off equals immobile. Eventually becomes more unpredictable