[parkinsonisms] Flashcards
Tremor
Rigidity/tone
Brady/hypokinesia
tremor at rest
pill-rolling
expressionless (hypomimesis)
decreased amplitude of movement
Neuroleptics
Metoclopramide (D-R antagonist)
Prochlorperazine (D-R2 antagonist)
Manganese
Copper (Wilson’s)
65
Mitochrondrial DNA dysfunction
degeneration of dopaminergic neurons in substantia nigra pars compacta
(associated with Lewy bodies)
5-10 years
Ropinirole
Pramipexole
[PD]: For sudden ‘off’ freezing, what medical Tx (in ‘rescue-pen’ form) is used?
Apomorphine
reduced sense of smell
constipation
depression
poor emotional content of speech decoding
Freezing whilst walking
Selegiline
Rasagiline
COMT inhibitors
entacapone/tolcapone
hepatic complications
LFTs monitor
Benzhexol
Orphenadrine
(anticholinergics)
Confusion in elderly
Carbidopa
madopar/Sinemet
Disease progression
Drug SE
Domperidone
VIVID
progressive supra nuclear palsy
Multi system atrophy
Lewy body dementia
Cortico-basal degeneration
Vascular parkinsons
partly dopamine responsive
Ablation of sub-thalamic nucleus