Parkinson's Disease Flashcards
1
Q
Aetiologies?
A
Idiopathic
Drug-induced
Vascular
Traumatic
2
Q
Pathology?
A
Degeneration of substantia niagra in basal ganglia –> loss of excitatory dopamine in striatum
3
Q
Signs and Symptoms?
A
Parkinsonism triad: pill-rolling tremor, rigidity and bradykinesia
Additional features: shuffling gait, loss of facial tone, postural difficulties
PD defined as 2 or more of parkinsonism without any focal signs
4
Q
Investigations and Findings?
A
Diagnosis purely clinical
Investigations exist but too expensive for routine use
5
Q
Management?
A
Levodopa but last resort
Deep brain stimulation
6
Q
Complications?
A
Progressive decline into sedentation
