Guillean - Barre Syndrome Flashcards
1
Q
Aetiologies?
A
Post infective disease
Causitive organisms: Camylobacter jejuni, EBV, Mycoplasma pneumonia
2
Q
Pathology?
A
Autoantibodies vs infective agents also acting on myelin sheath
Leads to acute demyelinating polyneuropathy
3
Q
Signs and Symptoms?
A
Bilateral ascending muscle weakness Pain Reduced/absent reflexes Sensory loss Autonomic signs Respiratory distress
4
Q
Investigations and Findings?
A
Nerve conduction study - slow conduction
Lumbar puncture - high protein in CSF
5
Q
Management?
A
Resuscitation
IV immunoglobulin
Plasma exchange
6
Q
Complications?
A
Permanent paralysis in ~10%
7
Q
Epidemiology?
A
More common in males 15-30 and 50-75
