Motor Neuron Disease Flashcards
1
Q
Aetiologies?
A
Idiopathic
Viral
Familial
2
Q
Pathology?
A
Progressive destruction of the UMN and LMN in the motor cortex, spinal cord and peripheral nerves
3
Q
Signs and symptoms?
A
Four main patterns:
ALS - lateral cortocospinal tract and anterior horn signs
Hand small muscle wasting
Bulbar/psuedobulbar palsies
Primary lateral sclerosis - purely UMN signs
4
Q
Investigations and findings?
A
Careful history and examination
MRI excludatory
5
Q
Management?
A
Palliative - MDT based
Sodium channel blocker prolongs life slightly
6
Q
Complications?
A
Prognosis bleak
7
Q
Epidemiology?
A
M > F, 3:2
