Parkinson's Disease

Question 1

Drugs that are OK to be used in PD psychosis

Answer 1

Quetiapine

Pimavanserin (Nuplazid)

Question 2

Preferred Drug Class for:
Elderly
Young

Answer 2

Elderly = carbidopa-levodopa

Young = dopamine agonists

Question 3

Brand/Formulations of Carbidopa-Levodopa

Answer 3

Sinemet = IR/CR tabs
Rytary = ER caps
Duopa = j-tube suspension

Question 4

What can you do to CR tabs vs ER caps?

Answer 4

CR tabs = can CUT, but NOT chew/crush

ER caps = sprinkle

Question 5

What is something you need to consider in the administration of carb-levo?

Answer 5

Separate from IRON or HIGH-PROTEIN MEAL

Question 6

MoA of COMTi and how does this correlate to the dosing

Answer 6

Inhibits peripheral metabolism of Levodopa, thus must be dosed with each dose of carbidopa-levodopa

Question 7

Brand / Generics of COMTi

Answer 7

Entacapone (Comtan)
+ Carb-Levo (Stalevo)

Tolcapone

Question 8

Dopamine Agonists Brand/Generics

Answer 8

Pramipexole (Mirapex)

Ropinerole (Requip)

Question 9

ADRs of Dopamine Agonists

Answer 9

Psychosis
Drowsiness
Orthostasis

Question 10

Drug used for Dyskinesias

Answer 10

Amantadine 100mg BID

Question 11

Drug used for Tremor in Young

Answer 11

Anticholinergic:

Benztropine (Cogentin)

Trihexyphenidyl