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NAPLEX - 2021 > DDI's > Flashcards

DDI's Flashcards

1
Q

Drugs that require acidic GI pH (reduced absorption with acid-suppressing drugs):

A

Rilpivirine (NNRTI)
Atazanavir (Protease Inhibitor)

Ledipasvir-Sofosbuvir (Harvoni)
Velpatasvir-Sofosbuvir (Epclusa)

Itraconazole
Posaconazole SUSPENSION [H2RA/PPI only]

Cefpodoxime (Vantin)
Cefuroxime (Ceftin/Zinacef)

Iron

Mesalamine

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2
Q

Antacids bind to these drugs:

A

INSTI: bictegravir, dolutegravir, elvitegravir, raltegravir

Fluoroquinolones / Tetracyclines

Isoniazid

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3
Q

CYP Inhibitors

A

GPACMAN
Grapefruit

Protease Inhibitors (Ritonavir)

Azoles (fluconazole, itraconazole, posaconazole, voriconazole, isavuconazonium)

C - cyclosporine, cobicistat, cimetidine

Macrolides (NOT azithromycin)

Amiodarone (& dronadarone)

Non-DHP CCB (verapamil / diltiazem)

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4
Q

CYP Inducers

A

PS PORCS

Phenytoin
Smoking
Phenobarbital
Oxcarbazepine
Rifampin (rifabutin / rifapentine)
Carbamazepine
St. John's Wort
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5
Q

Amiodarone/Dronadarone + Warfarin

A

2C9 Inhibition

Adding Amiodarone to Warfarin:
DECREASE Warfarin by 50%

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6
Q

Amiodarone + Digoxin

A

P-gp Inhibition

Adding Amiodarone to Digoxin:
DECREASE Digoxin by 50%

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7
Q

3A4 Inhibitors + Statins

A

Increased myopathy:
atorvastatin / lovastatin / simvastatin

Contraindicated:
Lovastatin / Simvastatin

Recommend:
Rosuvastatin / Pitavastatin / Pravastatin

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8
Q

2C9 Inhibitors + Warfarin

A

Azoles
Amiodarone
Bactrim
Metronidazole

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9
Q

2C9 Inducers + Warfarin

A

Rifampin

St. John’s Wort

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10
Q

Valproic Acid + Lamotridine

A

Valproic Acid = INHIBITOR (other anticonvulsants are INDUCERS)

Valproic Acid INCREASES [Lamotrigine]

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11
Q

2D6 Inhibitors

A

Amiodarone

Fluoxetine / Paroxetine (CI: tamoxifen)
Fluvoxamine

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12
Q

3A4 Opioid Substrates

A

Inhibitors = INCREASED []

Fentanyl
Hydrocodone / Oxycodone
Methadone

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13
Q

Opioid 2D6 Prodrugs

A

Ultrarapid Metabolizers = INCREASED []

Codeine
Tramadol

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14
Q

Serotonergic Toxicity

A 
SSRI/SNRI, TCA, Mirtazapine, Trazodone
MAOi
Buspirone
Dextromethorphan
Triptans / Dihydroergotamine
Lithium
Fentanyl / Methadone / Tramadol / Meperidine
St. John's Wort
Metoclopramide
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15
Q

Hyperkalemia

A

Bactrim
Canagliflozin
Drospirenone

ACEi / ARB / ARNi
Spironolactone / Eplerenone
Amiloride / Triamterene

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16
Q

QT Prolongation

A

Fluoroquinolones / Macrolides
Azoles

TCAs / SNRIs / Mirtazapine / Trazodone
Escitalopram / Citalopram

Thioridazine / Haloperidol / Ziprazidone

5HT3 Antagonists (ondansetron)

17
Q

3A4 Substrates

A 
Apixaban / Rivaroxaban / R-warfarin
Amlodipine
Tacrolimus / Sirolimus
Avanafil / Sildenafil /Tadalafil / Vardenafil
Ethinyl estradiol (Birth control)
18
Q

P-gp Substrates

A

Cyclosporine / Tacrolimus
Colchicine
Apixaban / Rivaroxaban / Dabigatran

NAPLEX - 2021 (18 decks)

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