Osteoporosis Flashcards
1
Q
Calcium Carbonate vs Calcium Citrate
A
Carbonate = 40% elemental
- Take WITH food
- AVOID with PPIs
Citrate = 21% elemental
Max absorption = 600mg
2
Q
Bisphosphonates
A
Alendronate (Fosamax)
Risedronate (Actonel / Altevia)
Ibandronate (Boniva)
Zoledronic Acid (Reclast) = IV (Zometa = malignancy)
3
Q
Bisphosphonates ADRs
A
1) Hypocalcemia
2) ONJ
Altevia (Risedronate) CI w/ acid-suppressing drugs
4
Q
SERMs
A
Raloxifene (Evista)
- Ppx of Postmenopause osteoporosis + breast cancer
Conjugated Estrogens + Bazedoxifene (Duavee)
- WITH a UTERUS
- increases Breast Cancer risk
5
Q
Denosumab
A
[Prolia]
[Xgeva] = malignancy
ADR: HYPO-calcemia
6
Q
Teriparatide (Forteo)
A
ADR: HYPER-calcemia
