Liver Disease

Question 1

HCV Treatment Names:

1) Protease Inhibitors
2) Replication Complex Inhibitors
3) NS5B Polymerase Inhibitors

Answer 1

HCV Tx = cure

1) Protease Inhibitors = “-previr” (Protease = “P”)
2) Replication Complex Inhibitors = “-asvir” (NS5”A”)
3) Polymerase Inhibitors = “-buvir” (NS5”B”)

Question 2

HCV Tx Considerations / ADR

Answer 2

Test for HBV

CI: Amiodarone WITH Sofosbuvir = bradycardia

Question 3

Mavyret

Answer 3

Glecaprevir + pibrentasvir

Question 4

Harvoni

Answer 4

Sofosbuvir + Ledipasvir

Question 5

Epclusa

Answer 5

Sofosbuvir + Velpatasvir

Question 6

Vosevi

Answer 6

Sofosbuvir + Velpatasvir + Voxilaprevir

Question 7

Harvoni, Epclusa, Vosevi acid-suppression considerations

Answer 7

1) Antacids = separate by 4 hours
2) H2RA = take at same time or separate
3) PPI = Contraindicated in EPCLUSA

Question 8

All HCV Tx DDI

Answer 8

Contraindicated with STRONG CYP3A4 INDUCERS

Question 9

Ribavirin Contraindication / ADR

Answer 9

Pregnancy X
Male partner must use protection

Hemolytic anemia

Question 10

HBV Treatments: NRTI

Answer 10

1) TDF (Viread)
2) TAF (Vemlidy)
3) Entecavir (Baraclude)
4) Adefovir (Hepsera)
5) Lamivudine (Epivir HBV)

Question 11

Portal Hypertension & Variceal Bleeding: ACUTE TX

Answer 11

1) Ocreotide (Sandostatin)

2) Vasopressin

Question 12

Portal Hypertension & Variceal Bleeding: Ppx

Answer 12

Goal HR = 55 - 60

1) Nadolol (Corgard)
2) Propranolol

Question 13

Portal Hypertension & Variceal Bleeding: Hepatic Encephalopathy

Answer 13

Removes ammonia:

1) Lactulose
2) Rifaximin

Question 14

Ascites Tx

Answer 14

Spironolactone + Furosemide

100mg:40mg Ratio