HIV Flashcards
Diagnosis of AIDS
1) CD4 < 200
2) AIDS-defining condition: opportunistic infections
Transmission of HIV
Blood, Semen, Vaginal, Rectal
BREASTMILK
Timing of Diagnosis Testing
1st) @ 2 weeks: HIV-1/HIV-2 Ag/Ab Immunoassay
2nd) @ 4-6 weeks: If (+), then Confirm with Antibody DIFFERENTIATION Immunoassay
- Determines if HIV-1 or HIV-2
3rd) @ 3 months: Ora-Quick Test
HIV Replication Steps & Rx Sites of Action: Step 1
Step 1) Binding /Attachment:
Maraviroc (Selzentry) = patient must have Trofile test for (+) CCR5 co-receptor to work
Ibalizumab-uiyk (Trogarzo)
HIV Replication Steps & Rx Sites of Action: Step 2
Step 2) Fusion
Enfuvirtide (Fuzeon)
HIV Replication Steps & Rx Sites of Action: Step 3
Step 3) Reverse Transcription
NRTI (Nucleoside Reverse Transcriptase Inhibitors)
NNRTI (Non-NRTI)
HIV Replication Steps & Rx Sites of Action: Step 4
Step 4) Integration
INSTI (Integrase Stand Transfer Inhibitors)
HIV Replication Steps & Rx Sites of Action: Step 5 / 6
Step 5) Transcription / Translation
Step 6) Assembly
NO DRUGS
HIV Replication Steps & Rx Sites of Action: Step 7
Step 7) Budding / Maturation
PI (Protease Inhibitors)
Initial Evalutation
1) CD4 count
2) HIV RNA Viral Load
3) Test HepB & Hep C
4) Pregnancy
Recommended Tx:
INSTI-based (1 INSTI + 1 or 2 NRTI)
One Pill, Once Daily
1) Biktarvy
2) Triumeq
3) Dovato
Biktarvy
Bictegravir (INSTI)
Emtricitiabine (NRTI)
TAF (NRTI)
Triumeq
Dolutegravir (INSTI)
Abacavir (NRTI)
Lamivudine (NRTI)
Dovato
Dolutegravir (INSTI)
Lamivudine (NRTI)
Two Pills
1) Tivicay + Truvada
2) Tivicay + Descovy
3) Isentress + Truvada
4) Isentress + Descovy
Tivicay
Dolutegravir
Preferred in Pregnancy