Parkinson/Alzheimer Drugs Flashcards
Parkinson Disease can be treated with?
BALSA: Bromocriptine Amantadine Levodopa (with carbidopa) Selegiline (and COMT inhibitors) Antimuscarinics
Bromocriptine, Pramipexole and Ropinirole MOA?
Dopamine agonists
Amantadine MOA? Use?
Increases dopamine release and decreases dopamine reuptake
Net: Increase Dopamine
Use: Parkinson and influenza A and rubella
Amantadine AE?
livedo reticularis-lace-like purplish discoloration of the skin
Cocktail to increase L-DOPA
Carbidopa+Levodopa (l-dopa)+Entacapone+ tolcapone
Purpose of Carbidopa, Entacapone+ tolcapone
Carbidopa=>blocks peripheral conversion of l-DOPA
to dopamine by inhibiting DOPA decarboxylase
Entacapone, tolcapone—prevent peripheral l-dopa degradation to 3-O-methyldopa (3-OMD) by inhibiting COMT
Which antimuscarinic can be used to stop the tremor and rigidity in parkinson patients?
Park your Mercedes-Benz.
Benztropine
Levadopa is what kind of an inhibitor? What will it do to Km and Vmax?
Noncomp. inhibitor
Vmax will decrease
Selegiline MOA?
MOA: Selectively inhibits MAO-B
Levadopa AE?
Dyskinesia following administration (“on-off” phenomenon)
Why doesn’t Selegiline cause Hypertensive crisis?
B/c tyramine is not consumed by MAOb
Memantidine MOA?
MOA: NMDA receptor antagonist; helps prevent excitotoxicity (mediated by Ca2+).
Drugs to Treat Alzheimer’s Disease? what class of drugs are they?
Grandma Doesn’t Remember me Today
Donepezil, galantamine, rivastigmine, tacrine
AChE inhibitors.
What drugs can be used for Huntington and their MOA?
Tetrabenazine and reserpine—inhibit vesicular monoamine transporter (VMAT); limit dopamine vesicle packaging and release.

Haloperidol—D2 receptor antagonist.
Triptans MOA and Use?
MOA: 5-HT1B/1D agonists=> vasoconstriction
Use: Acute migraine, cluster headache attacks
AE: Coronary vasospasm
