Neuromuscular blocking pharmacology Flashcards
1
Q
Which are the noncompetitive NMJ antagonists?
A
Depolarizing like Succinylcholine
2
Q
Depolarizing NMJ antagonists MOA?
A
MOA: 1. Prolonged depolarization 2. Desensitized Ach receptors
3
Q
Antidote to depolarizing NMJ antagonists?
A
Cholinesterase inhibitors
4
Q
Depolarizing NMJ AE?
A
Malignant Hyperthermia
5
Q
Which are the competitive NMJ antagonists?
A
Nondepolarizing drugs like “curare”
6
Q
Curare drugs act like?
A
MG
7
Q
Antidote to nondepolarizing NMJ antagonists?
A
cholinesterase inhibitors like Neostigimine
8
Q
Dantrolene MOA?
A
Prevents release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle.
9
Q
Baclofen MOA?
A
Inhibits GABAB receptors at spinal cord level, inducing skeletal muscle relaxation.
