Parkinson Flashcards
Levodopa
L-dopa to DA
與carbidopa 一起吃增加腦吸收
不可單獨和vit b6 使用
不可和MAO inhibitor 一起吃，須至少停藥兩週以上
Treat
Parkinsons Disease
Side effect
Depression/失眠/焦慮
On-off phenomenon
Akinesia 運動不能
Dyskinesia 運動失調
Wearing-off rxn
Glaucoma 一定發作
Bromocriptine
D2 agonist
indirect (煞車) @ putamen
Substantia nigra— putamen — GPe — sub-thalamus — GPi — thalamus
可用於劑量終點運動不能、開關現象及對levodopa逐漸失效的病患
Treat
Parkinson’s disease
Side effect
肢端血管收縮
手腳痛
肢端紅痛
Pergolide
Agonist
D1 direct
D2 indirect
可用於劑量終點運動不能、開關現象及對levodopa逐漸失效的病患
Treat
Parkinson’s disease
Side effect
肢端血管收縮
手腳痛
肢端紅痛
Pramipexole
D3 agonist
Remove H2O2 (ROS)
無phase I 代謝
可用於劑量終點運動不能、開關現象及對levodopa逐漸失效的病患
Treat
Parkinson’s disease
Side effect
肢端血管收縮
手腳痛
肢端紅痛
Ropinirole
D2 agonist
可用於劑量終點運動不能、開關現象及對levodopa逐漸失效的病患
Treat
Parkinson’s disease
Side effect
肢端血管收縮
手腳痛
肢端紅痛
Selegiline
MAOb inhibitor
Cause
Remove ROS—Prevent DA oxidized—DA increase
Treat
Parkinson’s disease
Rasagiline
MAOb inhibitor
Cause
Remove ROS—Prevent DA oxidized—DA increase
Treat
Parkinson’s disease
Tolcapone
COMT inhibitor
Prevent levodopa convert to 3OMD
Treat
Parkinson’s disease
Entacapone
COMT inhibitor
Prevent levodopa convert to 3OMD
No hepatotoxicity
Only act on peripheral (better than tolcapone)
Treat
Parkinson’s disease
Amantadine
Increase DA secretion
低效力療效短 和其他藥一起用
Treat
Parkinson’s disease
Side effect
手腳網狀青斑
禁忌
癲癇
鬱血性心衰竭
Benztropine
Acetylcholine blocker
Inhibit histamine receptor
Treat
Parkinson’s disease
Side effect
很多 (不好用
禁忌
BPH
腸胃疾病
Glaucoma
Biperiden
Acetylcholine blocker
Treat
Parkinson’s disease
Side effect
很多 (不好用
禁忌
BPH
腸胃疾病
Glaucoma
Orphenadine
Acetylcholine blocker
Treat
Parkinson’s disease
Side effect
很多 (不好用
禁忌
BPH
腸胃疾病
Glaucoma
Procyclidine
Acetylcholine blocker
Treat
Parkinson’s disease
Side effect
很多 (不好用
禁忌
BPH
腸胃疾病
Glaucoma
Trihexyphenidyl
Acetylcholine blocker
Histamine receptor blocker
Treat
Parkinson’s disease
Side effect
很多 (不好用
禁忌
BPH
腸胃疾病
Glaucoma
