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Endocrine Pharmacology > Parathyroid Drugs and Calcium Homeostasis > Flashcards

Parathyroid Drugs and Calcium Homeostasis Flashcards

1
Q

Primary hormonal regulators of Ca+2 metabolism

A

Parathormone
Vitamin D
Calcitonin

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2
Q

Secondary hormonal regulators of Ca metabolism

A

Glucocorticoids
Estrogen
Selective estrogen receptor modulators (raloxifene)

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3
Q

Non hormonal regulators of Ca metabolism

A

Bisphosphonates (alendronate)
Cinacalcet
Thiazides
Sodium fluoride

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4
Q

Used in hypoparathyroidism as an adjunct to Ca and vit D to reverse hypocalcemia

A

PTH (84 amino acids)

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5
Q

An anabolic agent stimulating bone formation in treatment of osteoporosis

A

Teriparatide (a recombinant PTH ) ( 34 amino acids)

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6
Q

Low intermittent subcutaneous administration of this drug for up to 2 years stimulates osteoblastic more than osteoclastic

A

Teriparatide

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7
Q

Long term exposure to excessive amounts of PTH can stimulate

A

Bone resorption more than bone formation

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8
Q

Acts on DNA receptor to synthesis protein for Ca transport

A

Vitamin D

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9
Q

When bone Ca is deficient, it increase ca deposition

A

Vit D

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10
Q

Used in treatment of
Hypocalcemia
Hypophosphatemia

A

Vitamin D

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11
Q

Used in treatment of osteoporosis

A

Vit D

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12
Q

Used in treatment of rickets and osteomalacia

A

Vit D

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13
Q

It acts on specific reactors on bone and kidney and decrease serum Ca and Po4

A

Calcitonin

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14
Q

Decrease bone resorption
Decrease calcium absorption
Decrease Ca reabsorption

A

Calcitonin

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15
Q

Used in treatment of
Hypercalcemia
Hyperprolactinemia
Osteoporosis

A

Salmon CT

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16
Q

Increase renal Ca excretion

A

Glucocorticoids

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17
Q

Decrease bone formation

A

Glucocorticoids

18
Q

Antagonize intestinal Vit D and stimulated Ca absorption

A

Glucocorticoids

19
Q

Used in treatment of hypercalcemia with lymphoma

A

Glucocorticoids

20
Q

Used in treatment of postmenopausal osteoporosis

A

Estrogen

21
Q

It’s prolonged cause many side effects such as breast and uterus carcinoma

A

Estrogen

22
Q

Stimulate estrogen receptors in bones and block them in the breast and uterus (mixed agonist- antagonist)

A

Selective estrogen receptor modulators ( Raloxifene)

23
Q

They are slowly released from bone during bone remodeling and the terminal half life appears to be greater than 10 years

A

Bisphosphonates (alendronate)

24
Q

Inhibit osteoclastic cell and induce apoptosis of osteoclasts

A

Bisphosphonates (alendronate)

25
Q

Used in treatment of osteoporosis

A

Bisphosphonates ( alendronate)

26
Q

Used in treatment of hypercalcemia associated with malignancy

A

Bisphosphonates (alendronate)

27
Q

Used in treatment of bone lesion associated with bone metastasis

A

Bisphosphonates (alendronate)

28
Q

From its side effects
Gastrointestinal distress
Renal impairment
Osteonecrosis of jaw

A

Bisphosphonates (alendronate)

29
Q

Works by an agonist activation at the calcium sensing receptors
Decrease secretion of PTH and lowering of serum calcium levels

A

Cinacalcet

30
Q

Used in treatment of hyperparathyroidism

A

Cinacalcet

31
Q

Used in treatment of hypercalcemia associated with parathyroid cancer

A

Cinacalcet

32
Q

Dec renal Ca excretion through inc effect of PTH in stimulating renal Ca reabsorption

A

Thiazides

33
Q

Used in prevention of dental caries

A

Sodium fluoride

34
Q

Treatment of osteoporosis

A

Na fluoride
Vit D
Calcitonin
Raloxifene
Bisphosphonates

35
Q

Causes of hyperglycemia

A

Hyperparathyroidism
Malignancy

36
Q

Management of acute hypercalcemia

A

Slaine diuresis
Hydrocortisone
Bisphosphonates
Hemodialysis

37
Q

Causes of hypocalcemia

A

Hypoparathyroidism
Chronic renal failure
Vit D deficiency

38
Q

Treatment of hypocalcemia

A

Calcium gluconate
Vit D
Thiazide diuretics

39
Q

Anti resorptive drugs used in treatment of osteoporosis

A

Bisphosphonates
Selective estrogen receptor modulators (raloxifene)
Calcitonin

40
Q

Anabolic drug used in treatment of osteoporosis

A

Teriparatide

41
Q

Anabolic anti resorptive drugs used in treatment of osteoporosis

A

Strontium ranelate

Endocrine Pharmacology (6 decks)

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