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Endocrine Pharmacology > Gonadal Hormones Inhibitors > Flashcards

Gonadal Hormones Inhibitors Flashcards

1
Q

Used as contraceptive pill

A

Estrogen

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2
Q

Used in dysfunction uterine bleeding

A

Estrogen

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3
Q

Replacement therapy in ovarian hypofunction

A

Estrogen

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4
Q

Used in treatment of atrophic vaginitis and osteoporosis

A

Estrogen

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5
Q

Used in treatment of cancer prostate

A

Estrogen

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6
Q

An anti estrogen

A

Clomiphene citrate (clomid)

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7
Q

Blocks estrogen receptor in hypothalamus and pituitary so increase fsh and lh so stimulate ovulation

A

Clomiphene ( clomid)

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8
Q

Used to stimulate ovulation in infertile women with normal pituitary function

A

Clomiphene ( clomid)

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9
Q

From its adverse effects are ovarian enlargement and hot flushes

A

Clomiphene (clomid)

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10
Q

Selective estrogen receptor modulators are

A

Tamoxifen
Raloxifene
Toremifene

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11
Q

Estrogen antagonist in breast and agonist in uterus and bone

A

Tamoxifen

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12
Q

Used in treatment of positive breast cancer and for primary prevention of breast cancer in women at high risk

A

Tamoxifen

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13
Q

From its adverse increase risk of endometrial cancer
Thrombotic complications

A

Tamoxifen

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14
Q

Agonist in bone but has no effect on uterus

A

Raloxifene

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15
Q

Used in treatment and prevention of postmenopausal osteoporosis

A

Raloxifene

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16
Q

It’s adverse effects are
Hot flashes
Thrombotic complications

A

Raloxifene

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17
Q

Enzyme that catalyzes the production of estrogens from androgenic precursors within the ovary and peripheral tissues

A

Aromatase inhibitors

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18
Q

New class of oral estrogen synthesis inhibitors

A

Aromatase inhibitors

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19
Q

Aromatase inhibitors are

A

Anastrozole
Letrozole
Exemestane

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20
Q

Are non steroidal competitive inhibitors of aromatase

A

Anastrozole and letrozole (femara)

21
Q

A steroidal irreversible aromatase inhibitors

A

Exemestane

22
Q

Used in treatment of postmenopausal women with estrogen receptor positive breast cancer who have received two to three years of Tamoxifen

A

Aromatase inhibitors

23
Q

Natural preparations of progesterone

A

Progesterone injection

24
Q

Synthetic preparations of progesterone

A

Medroxy progesterone acetate

25
Q

Used in
Contraceptive pill
Dysfunction uterine bleeding
Dysmenorrhea and endometriosis
Threatened abortion

A

Progesterone

26
Q

From its adverse effects are
Headache
Depression
Weight gain
Changes in lipido

A

Progesterone

27
Q

It is an anti progesterone

A

Mifepristone

28
Q

Competitive inhibitor of progesterone recey

A

Mifepristone

29
Q

Used with misoprostol to induce medical abortion in the first trimester

A

Mifepristone

30
Q

Natural preparations of androgens

A

Aldosterone and testosterone

31
Q

Synthetic androgens

A

Testosterone propionate

32
Q

Anabolic steroids

A

Nandrolone
Stanozolol

33
Q

From its contraindications
Prostatic tumors
Liver diseases
Children

A

Androgens

34
Q

From its adverse effects are
Reduction in spermatogenesis after stopping
Virilizing effects in females
Precocious puberty
Premature closure of epiphysis in children.
Cholestatoc jaundice

A

Androgens

35
Q

From 5 alpha reductase inhibitors

A

Finasteride

36
Q

Inhibit 5 alpha reductase enzyme

A

5, apha reductase inhibitors

37
Q

Used in treatment of
Benign prostatic hyperplasia
Male baldness
Hirsutism

A

5 alpha reductase inhibitors

38
Q

Competitive inhibitors of testosterone

A

Cyproterone and flutamide

39
Q

Competitive blocker oof both aldosterone and testosterone receptors

A

Spironolactone

40
Q

Used in treatment male hypersexuality

A

Cyproterone acetate

41
Q

Used in cancer prostate

A

Flutamide

42
Q

Testosterone receptors blockers are

A

Cyproterone acetate
Flutamide

43
Q

They are competitive inhibitors of testosterone receptors

A

Cyproterone acetate
Flutamide
Spironolactone

44
Q

They are competitive blockers of testosterone

A

Cyproterone
Flutamide

45
Q

It is a competitive blocker of both aldosterone and testosterone

A

Spironolactone

46
Q

Drugs used in hirsutism in females

A

Cyproterone acetate
Spironolactone

47
Q

Used in male hypersexuality

A

Cyproterone acetate

48
Q

Used in cancer prostate

A

Flutamide

Endocrine Pharmacology (6 decks)

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