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Endocrine Pharmacology > Gonadal Hormone Inhibitors 2 > Flashcards

Gonadal Hormone Inhibitors 2 Flashcards

1
Q

Single entity preparations are

A

Progesterone alone
Slow release progestin
Implantable progestin
Estrogen alone

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2
Q

Is a progesterone alone drug

A

Norethindrone ( norgestril)

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3
Q

Don’t affect lactation and don’t carry risk of thrombosis but can cause uterine bleeding

A

Norethindrone (norgestril)

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4
Q

From slow release progestin

A

Medroxy progesterone acetate

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5
Q

Given i.m every 3 months and suitable for unreliable women

A

Medroxy progesterone acetate

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6
Q

From implantable progestin preparations

A

L-norgestril ( Norplant)

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7
Q

Implanted subcutaneous

A

L-norgestril (Norplant)

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8
Q

Used within 72 hrs after sexual intercourse for 5 days

A

Estrogen alone

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9
Q

Inhibit ovulation

A

Combined preparations

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10
Q

Produce endometrial changes and interferes with contraction of cervix, uterus and fallopian tubes

A

Combined preparations

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11
Q

Dec sperm transport and fertilization

A

Combined preparations

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12
Q

Increase viscosity of cervical mucus

A

Combined preparations

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13
Q

Makes cervical mucus thick, though and hostile

Alter endometrial wall

A

Single entity ( progesterone only preparations)

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14
Q

Side effects of oral contraceptive

A

Cvs
CNS
Git
Endocrinal
Cancer

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15
Q

Side effects on cvs

A

Hypertension
Myocardial infarction
Thrombosis
Thromboembolic catastrophic

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16
Q

On CNS

A

Migraine headache
Cerebral hemorrhage (stroke)
Mood changes
Depression

17
Q

On git

A

Nausea and vomiting
Cholecystitis and gall stones
Cholestatic hepatitis and hepatotoxicity

18
Q

On endocrinal

A

Hyperglycemia and DM
weight gain and edema
Inhibition of lactation in lactating women
Menstrual irregularities
Loss of lipido
Acne
Hirsutism

19
Q

Cancer side effects

A

Increase risk of cancer

20
Q

Drug interactions that cause failure of contraceptive

A

Enzyme inducers ( rifampicin and phenytoin)
Broad spectrum ( tetracycline)
Paraffin oil( laxative) it Dec absorption of contraceptive pills

Endocrine Pharmacology (6 decks)

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