Gonadal Hormone Inhibitors 2 Flashcards
Single entity preparations are
Progesterone alone
Slow release progestin
Implantable progestin
Estrogen alone
Is a progesterone alone drug
Norethindrone ( norgestril)
Don’t affect lactation and don’t carry risk of thrombosis but can cause uterine bleeding
Norethindrone (norgestril)
From slow release progestin
Medroxy progesterone acetate
Given i.m every 3 months and suitable for unreliable women
Medroxy progesterone acetate
From implantable progestin preparations
L-norgestril ( Norplant)
Implanted subcutaneous
L-norgestril (Norplant)
Used within 72 hrs after sexual intercourse for 5 days
Estrogen alone
Inhibit ovulation
Combined preparations
Produce endometrial changes and interferes with contraction of cervix, uterus and fallopian tubes
Combined preparations
Dec sperm transport and fertilization
Combined preparations
Increase viscosity of cervical mucus
Combined preparations
Makes cervical mucus thick, though and hostile
Alter endometrial wall
Single entity ( progesterone only preparations)
Side effects of oral contraceptive
Cvs
CNS
Git
Endocrinal
Cancer
Side effects on cvs
Hypertension
Myocardial infarction
Thrombosis
Thromboembolic catastrophic
On CNS
Migraine headache
Cerebral hemorrhage (stroke)
Mood changes
Depression
On git
Nausea and vomiting
Cholecystitis and gall stones
Cholestatic hepatitis and hepatotoxicity
On endocrinal
Hyperglycemia and DM
weight gain and edema
Inhibition of lactation in lactating women
Menstrual irregularities
Loss of lipido
Acne
Hirsutism
Cancer side effects
Increase risk of cancer
Drug interactions that cause failure of contraceptive
Enzyme inducers ( rifampicin and phenytoin)
Broad spectrum ( tetracycline)
Paraffin oil( laxative) it Dec absorption of contraceptive pills
