Oral Antidiabetic Drugs

Question 1

From insulin secretagogues

Answer 1

Sulfonylureas
Meglitinide 👉🏻 repaglinides
d- phenylalanine derivatives 👉🏻 nateglinide

Question 2

From insulin sensitizers( euglycemic)

Answer 2

👉🏻 biguanides(metformin)
👉🏻Thaizolidinediones

Question 3

Alpha glucosidase inhibitors

Answer 3

👉🏻acarbose
👉🏻Miglitol

Question 4

Dpp IV inhibitors (_gliptin)

Answer 4

Sitagliptin
Vildagliptin
Saxagliptin

Question 5

Glucgon like peptide1 analogs ( GLP-1)

Answer 5

Exenatide
Liraglutide

Question 6

Amylin analogue

Answer 6

Pramlintide

Question 7

Sodium glucose cotransporter-2
( SGLT-2) (_gliflozin)

Answer 7

Canagliflozin
Dapagliflozin
Empagliflozin

Question 8

Dec glucose production in liver

Answer 8

Biguanides
Thiazolidinediones

Question 9

Dec glucose absorption in intestine

Answer 9

Alpha glucosidase inhibitors

Question 10

Increase insulin secretion in pancrease

Answer 10

Meglitinide
Sulfonylureas
Phenylalanine derivatives
Insulin

Question 11

Increase peripheral glucose uptake in adipose tissue and muscley

Answer 11

Biguanides
Thiazolidinediones

Question 12

It reduces glucose output from liver

Answer 12

Sulfonylureas

Question 13

Reduce glucagon serum level

Answer 13

Sulfonylureas

Question 14

Improve insulin sensitivity in periphery

Answer 14

Sulfonylureas

Question 15

Reduce HIBA1c by 0.9 to 2.5%

Answer 15

Sulfonylureas

Question 16

Used in diabetes type two

Answer 16

Sulfonylureas

Question 17

Contraindicated in
Obese people
Pregnancy
Major organ disease ( cardiac , haptic and renal)

Answer 17

Sulfonylureas

Question 18

Adverse effects of sulfonylureas
( Halt)

Answer 18

Hypoglycemic coma
Abdominal upset
Lipid deposit ( weight gain)
Teratogenicity
CNS manifestation ( headache)

Question 19

Drugs that replace sulfonylureas from plasma proteins leads to hypoglycemia

Answer 19

Aspirin
phenylbutazone
Sulfa

Question 20

Sulfonylureas displace oral anticoagulant lead to

Answer 20

Bleeding

Question 21

Hepatic enzyme inducers increase metabolism of sulfonylureas

Question 22

From hepatic enzyme inhibitors are

Answer 22

Cimetidine
Chloramphenicol
Allopurinol

Question 23

Augment their hypoglycemic effect by
Masking sympathetic manifestation of hypoglycemia
Decrease compensatory hepatic glycogenolysis

Answer 23

Beta blocker

Question 24

Thiazides, corticosteroids and oral contraceptive…… Effect of sulfonylureas

Answer 24

Decrease

Question 25

They stimulate pancreatic insulin secretion by binding to the sulphonylurea receptor and closing ATP - sensitive potassium channel

Answer 25

Meglitinide ( repaglinide) and d- phenylalanine derivatives (nateglinide)

Question 26

Has rapid onset and short duration of action

Answer 26

Meglitinide and phenylalanine derivatives

Question 27

Decrease HBA1c by
0.6-1.9%

Answer 27

Meglitinide (repaglinide) and phenylalanine derivatives (nateglinide)

Question 28

Hyperinsulinism
Less hypoglycemia
Less weight gain

Answer 28

Meglitinide
And phenylalanine derivatives

Question 29

Used in type 2 diabetes and with sulfur or sulfonylureas allergy

Answer 29

Meglitinide
Phenylalanine derivatives

Question 30

They control postprandial hyperglycemia

Answer 30

Meglitinide
Phenylalanine derivatives

Question 31

They are taken just before meal

Answer 31

Meglitinide
Phenylalanine derivatives

Question 32

Adverse effects of meglitinide and phenylalanine derivatives

Answer 32

Hypoglycemia