Parasympathomimetics

Question 1

What kind of drugs are parasympathomimetics?

Answer 1

Cholinergic drugs

Question 2

What are the two main groups we split the drugs in?

Answer 2

Direct and indirect

Question 3

Give the direct drugs:

Answer 3

Carbachol, buthanechol, metacholine, pilocarpine, acetylcholine ( non specific, non selective)

Question 4

Give the indirect drugs:

Answer 4

Physostigmine, Neostigmine, Pyridostigmine, Edrophorium, Organophosphates

Question 5

Use of Carbachol

Answer 5

Meritis - interuterine tablet, Glaucome - eye drops
Local use
Many side effects

Question 6

Use of bethanechol

Answer 6

Induction of GI peristasis, Urinary bladder atony

Question 7

metacholine

Answer 7

Atrial fibrillation, Vasodilation - ergot toxicosis (human)

Question 8

pilocarpine

Answer 8

Glaucome therapy, keratoconjuctivitis sicca (KCS)

Natural

Question 9

Physostigmine,

Answer 9

Glucoma, eye drop

Question 10

Neostigmine,

Answer 10

Glucoma, increase interstinal motility (myasthenia gravis treatment) eye drop

Question 11

Pyridostigmine,

Answer 11

Increase intestinal motility (myasthenia gravis),

Best oral

Question 12

Edrophorium,

Answer 12

Myasthenia gravis diagnosis

Question 13

Organophosphates

Answer 13

Ectoparasiticides, treatment of glucoma in humans

Question 14

Which drug can treat glaucoma, which increases the outflow of aqueous humour but has no effect on its production?

Answer 14

Pilocarpine

Question 15

What is the difference of the indirect and direct parasympathomimetic drugs?

Answer 15

Direct-binds to aCh receptors

Indirect -aCh esterase enzyme inhibition —> aCh degradation Is reduced

Question 16

Antidote of organophosphate

Answer 16

Atropine, pralidoxine