Antihistamines

Question 1

Which groups do we split antihistamines in to?

Answer 1

1st generation and 2nd generation

Question 2

Name the 1st generation antihistamines

Answer 2

Etylenediamines:chloropyramin, chlorpheniramine,
Ethanolamines: diphenhydramine, dimenhydrinate
Phenothiazine: promethiazine
Piperazines:hydroxyzine
Other; dimetinden, cyproheptadine

Question 3

Name the 2nd generation antihistamines

Answer 3

Loratadine,cetirizine, levocetirizine

Question 4

Indications in general for antihistamines:

Answer 4

Anaphylaxis

• Shock
• atopic dermatitis!
• cutaneous
• food adverse reactions
• FAD

Question 5

Pharmacological effects of antihistamine

Answer 5

vascular permeability epiglottis edema, angiedema

Question 6

Side effects of antihistamines in general

Answer 6

-CNS depression
-Cardiac toxixity
-Anticholinergic effect
-Appetite
depression

Question 7

Is antihistamines inverse agonists?

Answer 7

Yes

Question 8

Pharmacokinetics of antihistamines:

Answer 8

• Good oral absorption

- Met:liver CYP450 inducers