Parasympathetics

Question 1

Presynaptic choline transporter inhibitor

Answer 1

Hemicholinium

Question 2

presynaptic Ach vesicle transporter inhibitor

Answer 2

Vesamicol

Question 3

Presynaptic Ach release inhibitor

Answer 3

Botulinum

Question 4

Needed for succinylcholine removal

Answer 4

Butyrylcholinesterase or pseudocholinesterase

Question 5

succinylcholine AE

Answer 5

Apnea Hyperkalemia and Malignant Hyperthermia

Question 6

TX for Malignant Hyperthermia

Answer 6

Dantrolene

Question 7

M receptors and messengers

Answer 7

M1,M3,M5 are Gq
M2, M4 are Gi

Question 8

N receptors and messengers

Answer 8

both Nn and Nm are Na+K+

Question 9

Ach effects

Answer 9

D-Diarrhea
U-Urination
M-Miosis
B-Bradycardia
B-Bronchoconstriction
E-Emesis
L-Lacrimation
L-Lethargy
S- Salivation
S- Sweating

Question 10

M receptors and locations

Answer 10

M1- Gastric Glands
M2- Heart
M3- Visceral SM

Question 11

Nm antagonists

Answer 11

Atracurium, tubocurarine etc.

Question 12

Nn Antagonists

Answer 12

Hexamethonium, trimethaphan, and Mecamylamine

Question 13

Muscarinic Agonists and common use (5)

Answer 13

Acetylcholine, Bethanechol and Carbachol for bladder or GI, Pilocarpine for Glaucoma, Methacholine as Broncho provocative testing (>20% is asthma)

Question 14

Nicotina Agonist

Answer 14

Nicotine and Varenicline used for smoking cessation

Question 15

Varenicline AE

Answer 15

Suicidal Thoughts

Question 16

Reversible AcHase inhibitor (6)

Answer 16

Physostigmine used for glaucoma and Antimuscarinic Toxicity (atropine),
Neostigmine and Pyridostigmine for Myasthenia Graves and Edrophonium to test for MG,
Donepezil and Rivastigmine for Alzheimers

Question 17

Irreversible AcHase Inhibitor

Answer 17

Organophosphates like pesticides,
Nerve Gas like Tabun or Sarin

Question 18

Anticholinergic Drug Examples (8)

Answer 18

Atropine, Scopalamine, Ipratropium, tiotropium, Tropicamide, Benztropine, Trihexyphenidyl, Oxybutynin

Question 19

Atropine MOA

Answer 19

Reverse of Ach mnemonic:
Hot as a hare, blind as a bat, dry as a desert, full as a flask, red as a beet, mad as a hatter

Question 20

Scopalamine MOA

Answer 20

Motion sickness

Question 21

Ipratropium and Tiotropium MOA

Answer 21

Asthma and COPD

Question 22

Tropicamide MOA

Answer 22

Eye Mydriatic

Question 23

Benzatropine and trihexyphenadyl MOA

Answer 23

Parkinsonism and EPS

Question 24

Oxybutynin MOA

Answer 24

Incontinence

Question 25

Plant associated with Atropine

Answer 25

Belladonna or Nightshade, Datura stramonium or thorn apple.

Question 26

Organophosphate toxicity treatment

Answer 26

Atropine and Oxime

Question 27

Presynaptic sympathetic tyrosine hydrogenase inhibitor

Answer 27

Metyrosine

Question 28

Presynaptic sympathetic dopamine vesicle inhibitor

Answer 28

reserpine

Question 29

Presynaptic NE release Inhibitor

Answer 29

Guanethidine

Question 30

NET inhibitor (2)

Answer 30

Cocaine and TCA