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Selfmade > Parasympathetics > Flashcards

Parasympathetics Flashcards

1
Q

Presynaptic choline transporter inhibitor

A

Hemicholinium

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2
Q

presynaptic Ach vesicle transporter inhibitor

A

Vesamicol

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3
Q

Presynaptic Ach release inhibitor

A

Botulinum

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4
Q

Needed for succinylcholine removal

A

Butyrylcholinesterase or pseudocholinesterase

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5
Q

succinylcholine AE

A

Apnea Hyperkalemia and Malignant Hyperthermia

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6
Q

TX for Malignant Hyperthermia

A

Dantrolene

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7
Q

M receptors and messengers

A

M1,M3,M5 are Gq
M2, M4 are Gi

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8
Q

N receptors and messengers

A

both Nn and Nm are Na+K+

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9
Q

Ach effects

A

D-Diarrhea
U-Urination
M-Miosis
B-Bradycardia
B-Bronchoconstriction
E-Emesis
L-Lacrimation
L-Lethargy
S- Salivation
S- Sweating

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10
Q

M receptors and locations

A

M1- Gastric Glands
M2- Heart
M3- Visceral SM

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11
Q

Nm antagonists

A

Atracurium, tubocurarine etc.

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12
Q

Nn Antagonists

A

Hexamethonium, trimethaphan, and Mecamylamine

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13
Q

Muscarinic Agonists and common use (5)

A

Acetylcholine, Bethanechol and Carbachol for bladder or GI, Pilocarpine for Glaucoma, Methacholine as Broncho provocative testing (>20% is asthma)

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14
Q

Nicotina Agonist

A

Nicotine and Varenicline used for smoking cessation

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15
Q

Varenicline AE

A

Suicidal Thoughts

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16
Q

Reversible AcHase inhibitor (6)

A

Physostigmine used for glaucoma and Antimuscarinic Toxicity (atropine),
Neostigmine and Pyridostigmine for Myasthenia Graves and Edrophonium to test for MG,
Donepezil and Rivastigmine for Alzheimers

17
Q

Irreversible AcHase Inhibitor

A

Organophosphates like pesticides,
Nerve Gas like Tabun or Sarin

18
Q

Anticholinergic Drug Examples (8)

A

Atropine, Scopalamine, Ipratropium, tiotropium, Tropicamide, Benztropine, Trihexyphenidyl, Oxybutynin

19
Q

Atropine MOA

A

Reverse of Ach mnemonic:
Hot as a hare, blind as a bat, dry as a desert, full as a flask, red as a beet, mad as a hatter

20
Q

Scopalamine MOA

A

Motion sickness

21
Q

Ipratropium and Tiotropium MOA

A

Asthma and COPD

22
Q

Tropicamide MOA

A

Eye Mydriatic

23
Q

Benzatropine and trihexyphenadyl MOA

A

Parkinsonism and EPS

24
Q

Oxybutynin MOA

A

Incontinence

25
Q

Plant associated with Atropine

A

Belladonna or Nightshade, Datura stramonium or thorn apple.

26
Q

Organophosphate toxicity treatment

A

Atropine and Oxime

27
Q

Presynaptic sympathetic tyrosine hydrogenase inhibitor

A

Metyrosine

28
Q

Presynaptic sympathetic dopamine vesicle inhibitor

A

reserpine

29
Q

Presynaptic NE release Inhibitor

A

Guanethidine

30
Q

NET inhibitor (2)

A

Cocaine and TCA

31
Q
A

Selfmade (9 decks)

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