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COPD Dx Flashcards

1
Q

Epinephrine Treatment

A

Acute vasodilation and bronchospasm of anaphylaxis

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2
Q

Ephedrine difference of Epi

A

Longer duration, Oral activity, more pronounced central effect

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3
Q

Isoproterenol AE

A

Cardiac Arrhythmias

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4
Q

B2 selective drugs

A

Short Acting B2 Agonist and Long Acting B2 Agonist

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5
Q

Difference between Albuterol and Levalbuterol

A

R isomer of Albuterol

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6
Q

What are some SABA’s

A

Albuterol, Terbutaline and Levalbuterol

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7
Q

What are some LABA’s

A

Salmeterol, Formoterol and Bambuterol

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8
Q

Difference between SABA and LABA

A

LABA have high lipid solubility and are used only in combination with an inhaled corticosteriod

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9
Q

Why must LABA be given with ICS

A

LABA mask the symptoms of inflammation

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10
Q

MOA of SABA and LABA

A

increase cAMP which relax airway smooth muscle, inhibit the release of bronchoconstricting mediators from mast cells, as well as inhibit microvascular leakage and increase mucociliary transport.

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11
Q

AE of SABA and LABA

A

fine tremor, anxiety, tachycardia, muscle cramps, dry mouth, transient VQ mismatch, hypokalemia in prolonged use

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12
Q

Explain the hypokalemia from the AE of SABA and LABA

A

Increase Na K ATPase causes influx of K

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13
Q

MethylXanthine drugs

A

Theophylline, theobromine, and Aminophylline

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14
Q

MOA for MXthns

A

Inhibit PDEase enzymes PDE3, that causes bronchodilation, and PDE4, which decreases inflammation, and increase cAMP. Inhibit Adenosine receptors. Enhancement of histone deacetylation which inhibit inflammatory gene transcription.

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15
Q

Effects of cAMP in bronchus

A

Relax smooth muscles and reduction in the immune and inflammatory activity of specific cells.

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16
Q

AE of Mxthns

A

Narrow TI, tremors, medullary stimulation, convulsions, tachycardia, metabolized by PY-450

17
Q

Selective PDE4 inhibitor

A

Roflumilast aka. rolling on the floor

18
Q

Antimuscarinics

A

Ipratropium and tiotropium

19
Q

Antimuscarinic MOA

A

Competitive inhibitor of muscarinic receptors and prevents bronchoconstriction and decrease mucus production making it better for COPD.

20
Q

Antimuscarinic AE

A

dry mouth, urinary retention, and increase risk of dementia with age

21
Q

Corticosteroids MOA

A

inactivate NF-Kb

22
Q

Corticosteroids Indication

A

Inhalation for maintainance and Oral for Urgent treatment

23
Q

Corticosteroid AE

A

Oropharyngeal candidiasis, dysphonia, osteoporosis, and cataract

24
Q

5 Lipooxygenase Inhibitors

25
Q

Anti IgE

A

Omalizumab

26
Q

Mast Cell Stabilizers

A

Cromolyn and Nedocromil

27
Q

Zileuton AE

A

Hepatotoxic

28
Q

LTD4 receptor antagonist

A

Montelukast

29
Q

Function of LTD4

A

chemo attractant

30
Q

Omalizumab AE

A

Injection site reaction

Selfmade (9 decks)

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