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Selfmade > Antihyperlipidemics > Flashcards

Antihyperlipidemics Flashcards

1
Q

Statin MOA

A

Inh. Rate limiting step in cholesterol biosynthesis-> liver increase the uptake of cholesterol from plasma -> Upregulation of hepatic LDL receptors & decrease plasma LDL

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2
Q

statin AE

A

Myopathy : related with Niacin and Fibrates use. Hepatotoxicity

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3
Q

Cole- MOA

A

,Bile acid sequestrants: forms an insoluble complex that is excreted in the feces

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4
Q

Cole- AE

A

Fat malabsorption and Fat soluble vitamin malabsorption

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5
Q

Cole- CI

A

Hypertriglyceridemia

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6
Q

Cholestyramine is used in what disease

A

Primary Biliary obstruction

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7
Q

Niacin

A

Vit B3

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8
Q

Niacin Drug Class

A

Nicotinic Acid

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9
Q

Niacin MOA

A

Inhibits Hepatic Sens. Lipase and Hep. VLDL synthesis and increase Lipoprotein Lipase Act

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10
Q

Niacin AE

A

Flushing (Tx: NSAIDS) Hyperuricemia Drug Interaction: Statins = myopathy

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11
Q

Fibrates MOA

A

PPAR-a agonist increase LPL

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12
Q

Fibrates AE

A

Myopathy, Hepatitis, & Cholelithiasis

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13
Q

Fibrates Use

A

Used primarily for hypertriglyceridemia

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14
Q

Cholesterol uptake inhib.

A

Ezetimibe

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15
Q

Ezetimibe MOA

A

Inhibits NPC1LP cholesterol transporter in the intestinal brush border

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16
Q

PCSK9

A

Evolocumab and Alirocumab

17
Q

PCSK9 MOA

A

inhibits PCSK9 decreasing Hepatocyte LDL receptors

18
Q

PCSK9 AE

A

Injection site rx and Neurocognitive effects

19
Q

Orlistat

A

Obesity Dx that blocks gastric and pancreatic lipases

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