Mucolytics and Antitussives

Question 1

Name 4 types of nasal decongestants

Answer 1

Phenylephrine, pseudoephedrine, xylometazoline, oxymetazoline.

Question 2

Phenylephrine MOA

Answer 2

Post synaptic a receptor stimulant

Question 3

Pseudoephedrine MOA

Answer 3

Both a and b agaonist properties

Question 4

Xylometazoline MOA

Answer 4

A1A and A2B adrenergic

Question 5

Oxymetazoline MOA

Answer 5

Long Acting A1 snd A2A agonist

Question 6

Antitussives

Answer 6

Dextromethorphan and Benzonatate

Question 7

Dextromethorphan MOA

Answer 7

Opiod Derivatives that decreases the sensitivity of cough receptors in the medullary center

Question 8

Dextromethorphan AE

Answer 8

Less constipation than codeine

Question 9

Benzonatate MOA

Answer 9

Non narcotic local analgesic for stretch receptors and thus reduces the cough reflex at its source

Question 10

Expectorants

Answer 10

N-acetylcysteine and Guaifenesin

Question 11

N-acetylcysteine MOA

Answer 11

Open disulfide bonds reducing the viscosity of mucous. Also works as an antioxidant

Question 12

Guaifenesin MOA

Answer 12

Increases the volume and reduces the viscosity of secretions in the trachea and bronchi

Question 13

Drugs for Cystic Fibrosis

Answer 13

Dornase Alfa, Ivacftor and Lumacaftor, Acetyl cysteine

Question 14

Dornase Alfa MOA

Answer 14

Recombinant human deoxyribonuclease I that cleaves the extracellular DNA from invading neutrophils to decrease mucus viscosity

Question 15

Ivacaftor and Lumacaftor MOA

Answer 15

Only used in Pts with mutation G551D by increasing Cl- ion transport channel open probability

Question 16

Most common CF mut

Answer 16

Delta F508

Question 17

Acetyl cysteine MOA

Answer 17

Donates Sh group

Question 18

Drugs for Pul HTN

Answer 18

Bosentan,Epoprostenol, Sildenafil

Question 19

Bosentan MOA

Answer 19

ET 1 Antagonist

Question 20

Epoprostenol MOA

Answer 20

PGI Analogue leads to V.D.

Question 21

Sildenafil MOA

Answer 21

PDE5 antagonist