Antibodies

Question 1

Antinuclear Antibody (ANA)

9 possible Answers

Answer 1

1. SLE
2. Drug Induces Lupus, Sjörgen
3. Polymyositis and Dermatomyositis
4. Juvenile Idiopathic Arthritis, Raynauds
5. Mixed Connective Tissue
6. Autoimmune Hepatitis
7. Scleroderma or Systemic Sclerosis
8. T1 Diabetes
9. Psoriasis.

Question 2

Antineutrophil Cytoplasmic Antibodies (ANCA)

Answer 2

cANCA or Antiproteinase 3 PR3-ANCA:
Granulomatosis with polyangiitis aka Wegener Granulomatosis

pANCA or Myeloperoxidase MPO ANCA:
Microscopic Polyangiitis
Eosinophilic Granulomatosis with polyangiitis aka Churg Strauss Polyarteritis Nodosa
Ulcerative Colitis

Question 3

Anti-dsDNA

Answer 3

SLE

Question 4

Anticentromere Antibody (ACA and Anti Scl 70)

Answer 4

Scleroderma- Diffuse and Limited aka CREST

Question 5

CREST

Answer 5

Calcinosis
Raynauds
Esophageal Dysfunction
Sclerodactyly
Telangiectasia

Question 6

Antihistone Antibodies (AHs)

Answer 6

SLE
Drug induces Lupus
Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis

Question 7

Cyclin Citrullinated Peptide (CCP)

Answer 7

Rheumatoid Arthritis

Question 8

Rheumatoid Factor (RF)

Answer 8

Rheumatoid Arthritis or Sjörgen

Question 9

Anti Jo 1

Answer 9

Polymyositis

Question 10

Anti SS A (Ro) and Anti SS B (La)

Answer 10

Sjörgen

Question 11

Anti Smith (Sm)

Answer 11

SLE

Question 12

Anti Tissue Transglutaminase and Anti Gliadin

Answer 12

Celiac

Question 13

Antiphospholipid Antibodies

Answer 13

APLA- Lupus- Young Women with multiple failed pregnancies.

Question 14

Diabetes related Autoantibodies

Answer 14

Islet Cell Cytoplasmic Autoantibodies
Glutamic Acid Decarboxylase Autoantibodies
Insulinoma Associated 2 Autoantibodies
Insulin Autoantibodies
Zinc Transporter 8 Autoantibodies

Question 15

Intrinsic Factor Antibodies

Answer 15

Pernicious Anemia

Question 16

Thyroid Antibody

Answer 16

Graves Disease

Question 17

Antimitochondrial Antibody

Answer 17

Primary Biliary Cholangitis

Question 18

Smooth Muscle Antibody and F actin Antibody

Answer 18

AI Hepatitis

Question 19

Acetylcholine Receptor Antibody

Answer 19

Myasthenia Gravis

Question 20

Anti Glomerular Basement Membrane (GBM)

Answer 20

Goodpasture Syndrome

Question 21

SLE Antibodies

Answer 21

ANA
Anti dsDNA
AHA
Anti Sm (Smith)

Question 22

Antibodies in pregnant mom that may affect the fetus:

Answer 22

1. Graves Disease (Anti-TSH)- Fetal Thyroid Destruction
2. Sjrögen (Anti-Ro)- Fetal Heart Block
3. Myasthenia Gravis (Anti-postsynaptic ACh Receptor)- Fetal Arthrogryposis
4. Maternal Antobodies against surface platelets- Fetal Hemorrhage