Parasympathetic Nervous System Drugs

Question 1

Primary neurotransmitter and receptor of PNS

Answer 1

Acetlycholine, binds to cholinergic receptors

Question 2

Nicotine effects

Answer 2

↑ Sympathetic activity (↑ HR)
↓ Parasympathetic activity

Question 3

Nicotine overdose side effects

Answer 3

nausea and weakness

Question 4

Nicotine patch education

Answer 4

• avoid using nicotine products while wearing a path, could lead to OD
• remove at bedtime

Question 5

Muscarinic agonists MOA

Answer 5

• bind to muscarinic receptors
• Inhibit AChE to prevent Ach breakdown to ↑ Ach

Question 6

Muscarinic agonist examples

Answer 6

Pilocarpine
Bethanechol
Pyridostigmine
Physostigmine
Donepezil

Question 7

Pilocarpine uses

Answer 7

glaucoma: contracts ciliary muscle to allow drainage

Question 8

Bethanechol uses

Answer 8

urinary retention: stimulates bladder

Question 9

Pyridostigmine uses

Answer 9

reverse muscle weakness in patients with MG

Question 10

Physostigmine uses

Answer 10

acetylcholinesterase inhibitor for
organophosphate insecticide poisoning and anticholinergic toxicity

Question 11

Donepezil

Answer 11

enhances memory in some Alzheimer’s patients