Anticholinergics Flashcards
Cholinergic receptors
respond to acetylcholin
Acetylcholine effects
urination
myosis
bradycardia
bronchospasm
emesis
lacrimation
salivation, sweating
cholinergic crisis
excess Ach
Salivation
Lacrimation
Urination
Defecation
Gastrointestinal distress
Emesis
(SLUDGE)
Anticholinergics aka
Ach-blockers
cholinergic antagonists
parasympatholytics*
*block parasympthetic activity, more sympathetic activity
Anticholinergics SE
contipation
urinary retention
mydriasis
tachycardia
bronchial dilation and dryness
antiemetic (effective against N/V)
dry eye
dry mouth
↓sweating, ↑body temp
examples
Atropine
Scopolamine
Benzotropine
Ipratropium
Hyoscyamine
Oxybutynin
Anticholinergic toxicity
cognitive interference
confusion
restlessness
dry mouth
constipation
urinary retention
bowel obstruction
dilated pupils
blurred vision
⬆HR
⬇sweating
“mad as a hatter, dry as a bone, hot as a desert” whatever that means
Physostigmine
acetylcholinesterase inhibitor
for antidote for anticholinergic toxicity and
organophosphate insecticide poisoning
Atropine uses
- tx of bradycardia
- reduce salivation during anasthesia/surg
- dilate pupils
- tx of organophosphate poinsoning
Scopolamine uses
- prevent N/V d/t motion sickness or meds used during surg
Benztropine (Cogentin) use
tremors d/t Parkinson’s
Ipratropium (Atrovent) use
- bronchodilator
- tx of COPD
Hyoscyamine (Levsin) uses
- GI spasms
- overactive bladder
- IBS
Anticholinergics effect on CNS
- mess with cognition
- short-term memory loss
- confusion
- delirium
- disorientation
- hallucinations
Oxybutynin uses
relaxes overactive bladder
