Adrenergics Flashcards
adrenergic agonists and sympathomimetics
1
Q
Alpha-1 Receptor Agonists MOA
A
peripheral vasoconstriction to ⬆ BP
2
Q
Alpha-1 Receptor Agonists used for
A
Nasal congestion:
- constricts arterioles to ⬇ nasal blood flow
Conjunctival congestion
Open-angle glaucoma
- ⬇ intraocular pressure
- dilate pupils
3
Q
- ephedrine
- naphazoline
- oxymetazoline
- phenylephrine
- tetrahydrozoline
are all examples of…
A
Alpha-1 Receptor Agonists
4
Q
Alpha-2 Receptor Agonists MOA
A
- stimulating Alpha-2 receptors ↓ sympathetic output
5
Q
Alpha-2 Receptor Agonists uses
A
- antihypertensive
- sedative
- ADHD
6
Q
Alpha-2 Receptor Agonists examples
A
- clonidine (ADHD)
- tizanidine (muscle relaxer)
7
Q
Beta-1 Receptor Agonists MOA
A
- affects heart
- ↑HR and contractility
- kidneys release renin
- positive inotropic, chronotropic, dromotropic
8
Q
Beta-1 Receptor agonists uses
A
- cardiac arrest
- acute heart failure
- shock
9
Q
Beta-1 Receptor agonist example
A
Dobutamine (↑ cardiac output for heart failure & shock)
10
Q
Epinephrine MOA
A
- alpha and beta adrenergic receptors
- bronchial smooth muscle relaxtion
11
Q
Epinephrine uses
A
- bronchospasm (during asthma attack)
- wheezing
- dyspnea (during anaphylaxis)
- severe allergic reactions
- cardiac resuscitation
- hypotension in severe shock
- local injection to control superficial bleeding
12
Q
Epinephrine contraindications
A
- use in fingers, toes, penis, nose when used with local anesthetic (d/t epi causing vasoconstriction
- narrow-angle glaucoma
- elderly with preexisting CV disease
13
Q
Norepinephrine (Levophed) MOA
A
- peripheral vasoconstrictor
- inotropic stimulator of heart
- dilator of coronary arteries (beta-adrenergic)
- doesn’t stimulate beta2-adrenergic receptors of lungs
14
Q
Norepinephrine (Levophed) uses
A
- life threatening hypotension and shock
- continuous infusion until low BP is under control
15
Q
Beta-2 Receptor agonist MOA
A
- smooth muscle relaxation in lungs, GI, uterus, and liver
