Non-bronchodilating Drugs Flashcards
(corticosteroids and LTRAs
1
Q
Corticosteroid routes
A
Inhal, PO, IV
2
Q
Glucocorticoids
A
natural (cortisol) or
synthetic
3
Q
Corticosteroid MOA
A
- reduce inflammation
- enhance action of beta-adrenergic agonists
4
Q
Corticosteroid therepeutic effects
A
- several weeks before full effect
- tx of persistent asthma
- prevent asthma attacks
- IV tx of acute exacerbation
5
Q
Corticosteroid nursing implications
A
- doses must be tapered off when stopping
- risk of bone suppression (caution in children)
- may need increased diabetes meds
- assess for underlying adrenal d/o
6
Q
Leukotriene Receptor Antagonists MOA
LTRAs
A
- prevent leukotrienes from attaching to receptors on immune cells (circulating and in lungs)
- reduce inflammation
- decrease mucous secretions
- reduce vascular permeability
- prevent mobilization of WBCs into lungs
7
Q
LTRA classes
A
- Zileuton
- Montelukast
8
Q
LTRA
Montelukast therapeutic effects
A
- preventative
- long term tx of asthma
- daily dose, PO
9
Q
LTRA
Montelukast SE
A
- heachache
- nausea
- diarrhea
10
Q
LTRA
Montelukast considerations
what to monitor
A
- monitor liver function
11
Q
LTRA
Montelukast interactions
A
phenobarbital and rifampin
by effecting CYP3A4 metabolism
