Parasitology - Exam 1 Lecture 10 (ascarids) Flashcards

1
Q

Discuss ascarids - the basics

A
  • Very common
  • large nematodes
  • adults live in smallk intestine
  • some species are zoonotic
  • ## huge reproductive potential and eggs survive in envionrment for months
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2
Q

What ascarids infect the different species

A
  • Toxocara canis –> dogs
  • Toxocara cati: cats
  • Toxocara leonina –> in dogs and cats and zooo animals
  • ## Baylisascaris procyonis in racoons
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3
Q

Illustrate the different different parasites and the organs in wgich they infect

A
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4
Q

Discuss the Toxocara canis life cycle

A
  • Adult worms in intestines mate and produce eggs whch are pooped inot the enuivornment
  • Larva develops within the egg to the infectious L3. NOTE THAT THIS OCCURS IN THE ENVIORNMENT
  • Dog ingests larvated egg
  • Larvae hatches out in intestine and enters the blood stream:
    - some somatic migration –> encysts in tissues
    - some take tracheal route –> back to intestine to mature and produce eggs –> NOTE THAT THIS OCCURS IN THE HOST ANIMAL
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5
Q

Discuss thr Toxocar canis life cycle

A
  • somatic migration can occur in any malmallian host (mouse, rabit, humans, etc)
    - becomes a paratenic host whre the parasite arrests in the infective larval stage but does not develop further –> waits for the paratenic hiost to be eaten by the definitive host
  • a dog can become infected by eating a paratenic host that contains Toxocar canis arrested by larvae
    - ingestion of L3 from tissues results in patent infection in dogs
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6
Q
A
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7
Q

When considering Toxocara Canis, discuss the transmission

A

Four ways in which a dog can be infected:
1) ingest a larvated egg from the enivornment
2) eats an infected paratenic host
3) Transplacental transmission –> arrested L3 in the tissues of the dam are reactivated and migrate to the placenta during pregnancy > infects pups in utero
4) Transmammary transmission –> arrested L3 in the tissues of the dam are reacivated and migrate to the mammary gland > ingested by pups in the milk

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8
Q

Again, when consideirng toxicara canis, discuss the transmision routes

A

Transplacental transmission:
- larvae migrate thorugh lungs of thr pups
- Cause damage and inflammation
- Rare but the most commonly fatal route

Transmammary transmision:
- larva ingested by pups> go straught to the small intestine and develop into adults

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9
Q

Now, discuss the transmision and life cycle of toxocara canis

A
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10
Q

Discuss the opathologic effects of toxocar canis

A
  • severity of clinical signs depend on hoist factors and worm burden
  • Adult worms in the intestinal tract
  • Smal numbers of intestinal worms: mild mucoidn enteritis, mild diahhrea, often asymptomatic
  • **Large numbers of intestinal worms:* obstruction or rupture of intestine, blockage of bile or pnacreatic ducts
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11
Q

Discuss the clinicasl signs of toxocar canis

A
  • pathogenic primarily in puppies, adults tend to be asymtpomatic
  • **adult worms ** in the inestine –> live worms in feces or vomtius
  • **larval worms ** mirgrating thorugh the lungs
  • ## General ill thrft
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12
Q

Discuss the diagnsois of toxocara canis

A
  • Fecal floats to identiofy the eggs
  • fecal antigen tests
  • young puppies - presum,toive because of clinical history of dam and kennel
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13
Q

Discuss the life cycle of toxocara cati

A

Different toxocar canis in dogs in that 1) very few undergo somatic migration in cats –> encysts in tissues 2) **almost all ** take tracheal route –> back to intestine to mature and produce eggs

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14
Q

Discuss the transmission routes for Toxocara cati

A

Three ways in which a cat can be infected:
1) ingests a larvated eggs from the eniuvonrment
2) Eat an infected paratenic host –> THIS IS THE MAJOR TRANSMISSION ROUTE FOR TOXOCAR CATI
3) Transmammary transmision is possoible but ONLY if the queen is infected during lacrtation

TRANSPLACENTAL TRANSMISSION DOES NOT OCCUR

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15
Q

DISCUSS THE DIAGNOSIS FOR TOXOCAR CATI

A

Same as Toxocara canis
fecal floats to identify the eggs

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16
Q

Discuss the species known as toxocaris Leonina and its life cycle

A

The main differences between this and that of Toxocar cati are that 1) takes less than 1 week for infectious L3 to develop in the egg –> NOTE that thiss occurs in the envornment. Next, 2) Larvae hatches out in the inestine and **molts L4 > L5, adult; also, it does not migrate in dogs and cats ** NOTEthat this occurs in dogs and cats

17
Q

discuss the basics of Toxocaris leonina transmission

A
  • Two ways in which an animnal can be infected:
  • 1) Ingest a **larvated egg ** from the enivonrment
  • 2) Eat an infected paratenic host –> this is the majior transmision route

transmammary and transplacental transmission does not occur

18
Q

Discuss Bayliascaris

A

Baykliascaris is an important zoonotic nematode
Definitive host: racoon
Life cyclke: same as Toxocara canis –> it undergoes somatic migrauion in any mammal

Larva are muych larger than T. Canis, grow as they migrate and wander aggresivekly

19
Q

why are toxocara canis and abylisacascaris considered to be important zoonotic pathogens/

A

Toxocara canis and Bayliasacris are important zoonotic pathogens

  • ## These parasites cause **visceral larval ligrans (VLM) ** and ocular larval migrans (OLM) in humans
20
Q

Discuss viceral larval migrans

A
  • usually seen in children under 5 years old
  • Damage is due to the L3 larvae migrating through the tisssues and the iummune response trying to stop them
  • ## Symptoms vary from asymptomatic to very severe –> can have cardiac, pulmonary, neurologic involvement, dpendsing on where the larvae migrate
21
Q

Discuss ocular larval migrans

A

Eosinophilic granuloma surroundsng in the larva in the retina –> can be mistaken for retinoblastoma

22
Q

Discuss control and prevent human inection in terms of ascarids

A
  • Treat pets –> deworm regualry (prevent transmission from dams to puppies; prevent puppies from shedding eggs)
  • Reduce envionmentakl contamination: recue umber of stray dogs

educate clients

23
Q

Discuss dog and puppy treatment in relation to ascarids

A

Anthelmintic arsenal:
- pyrantel maoate
- piperazine
- fenbendaz\ole
- macrocycli lactones

Treat puppies eery two weks starting at tweks old until 3 months old:
- pyrantel pamoate –> labeled for use in puppies 2 weeks and olde; treat dams at the same time

Piperazine and fenbendazole in puppies > 6 weeks old

24
Q

Again, discuss the treatment for dogs and puppies when considering Ascarids

A

Treat kactating dams to prevent transpacental and transmammary transmission –> both options are off label

1) **fenbendazole __> daily from day 42 of gestation until 14 days after whelping **
2) High dose ivermectin –> not recommended by manufacturer

25
Q

Discuss the treatment of ascarids in cats and kittens

A
  • preganant queens do not need to be treated
  • Treat both lactating queen and kittens at 2-4-6-8 weeks of age woth pyrantel pamoate
26
Q

Discuss the envionmental control of ascarids

A
  • it is really hard to kill ascarid eggs –> they are ot affected by many household cleaners
  • decrease egg shedding in envionrment –> deworm regularly
  • clean up –> dispose of feces
  • Get rid of eggs–> Bleach to remove the protein coat from the egg