Paraneoplastic Syndromes Flashcards
ADH
Effect- SIADH
Neoplasm- Small cell lung carcinoma and intracranial neoplasms
ACTH or ACTH-like peptide
Effect- Cushing’s syndrome
Neoplasms- small cell lung carcinoma
PTHrP
Effect- Hypercalcemia
Neoplasm- Squamous cell lung carcinoma, renal cell carcinoma, breast cancer
1,25-(OH)2 D3 (calcitrol)
Effect- Hypercalcemia
Neoplasm- Hodgkin’s lymphoma, non-Hodgkin’s lymphomas
EPO
Effect- polycythemia
Neoplasm- renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, pheochromocytoma
Antibodies against PRE synaptic Ca2+ channels at NMJ
Effect- Lambert- Eaton muscle syndrome (muscle weakness not fixed with AChE blockers)
Neoplasm- small cell lung carcinoma
Neuroblastoma
Opsoclonus (non-rhythmic conjugate eye movements) and myoclonus