Paracetamol

Question 1

Indications for use

Answer 1

fever, Pain, analgesic, neuralgia

Question 2

MOA

Answer 2

Blocks COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.

Question 3

Pharmacological effects

Answer 3

Antipyretic, analgesic

Question 4

Pharmacokinetics (way of administration, metabolism, elimination, T1/2)

Answer 4

Oral, IV , Rectal/ Liver. Urine 1 to 3 hours (24h)

Question 5

Overdose effects

Answer 5

Hepatotoxicity, nephrotoxicity

Question 6

Side effects

Answer 6

Rash, diarrhea, nausea

Question 7

Contraindications for use

Answer 7

Hypersensitivity, liver and renal failure, hepatic impairment

Question 8

Drug interactions

Answer 8

When used simultaneously with anticoagulants, a slight or moderate increase in prothrombin time is possible.

When used simultaneously with anticholinergic drugs, the absorption of paracetamol may be reduced.

Question 9

Interactions with products (meal), drinks

Answer 9

No interactions but recommended with meals

Question 10

Children

Answer 10

10-15 mg /kg

Question 11

Elderly patients

Answer 11

500-650mg

Question 12

Pregnant women

Answer 12

Category C

Question 13

Overdose treatment

Answer 13

determine content of paracetamol, N-acetylcysteine ​​within 10 hours after an overdose. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.