Memantine

Question 1

Indications for use

Answer 1

Cognitive enhancer , Alzheimer (mod – sev)

Question 2

MOA

Answer 2

Inhibits glutamate transmission

Question 3

Pharmacological effects

Answer 3

Treat dementia

Decrease impairment of cognitive functions

Question 4

Pharmacokinetics (way of administration, metabolism, elimination, T1/2)

Answer 4

oral metabolize on liver (enzyme CYP450), renal excretion (The elimination half-life is about 60 to 80 hours)

Question 5

Overdose effects

Answer 5

Seizures, heart disturbance, tachycardia

Question 6

Side effects

Answer 6

dizziness, constipation, hallucinations

Question 7

Contraindications for use

Answer 7

Hypersensitivity, kidney or Liver problem, pregnancy or breastfeeding

Question 8

Drug Interaction

Answer 8

has no known severe interactions with other drugs.

reduce the effects of barbiturates and antipsychotics.

Question 9

Interactions with products (meal), drinks

Answer 9

X no

Question 10

Children

Answer 10

contraindicated

Question 11

pregnancy

Answer 11

cat B

Question 12

Elderly

Answer 12

5-10 mg

Question 13

Overdose - what to do

Answer 13

gastric lavage, forced diuresis, symptomatic treatmentbecause there is no specific antidote: gastric lavage, activated charcoal, acidification of urine.