Diclofenac

Question 1

Indications for use

Answer 1

Mild – mod pain, analgesic

Question 2

MOA

Answer 2

inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) leads to decrease of prostaglandin precursor

Question 3

Pharmacological effects

Answer 3

Analgesic, anti-inflammatory

Question 4

Pharmacokinetics (way of administration, metabolism, elimination, T1/2)

Answer 4

Oral, IM, rectal, topical gel, ophthalmic preparation, time 2h, liver, urine

Question 5

Overdose effects

Answer 5

hepatoxicity, dizziness, headache

Question 6

Side effects

Answer 6

nausea, vomiting, headache

Question 7

Contraindications for use

Answer 7

Hypersensitivity, ulcers, liver failure, heart failure

Question 8

Drug interactions

Answer 8

Decrease effect of ACE & betablockers

Question 9

Interactions with products (meal), drinks

Answer 9

No effect

Question 10

Children

Answer 10

2,3 mg/ kg day

Question 11

Elderly patients

Answer 11

50mg

Question 12

Pregnant women

Answer 12

Category C ( 1 oe 2 trimester)
Category D ( 3 trimester)

Question 13

Overdose treatment

Answer 13

gastric lavage, administration of activated carbon, symptomatic therapy aimed at eliminating increasedblood pressure, renal dysfunction, convulsions,gastrointestinalirritation , respiratory depression