Hydroxyzine

Question 1

Indications for use

Answer 1

anxiety and tension associated with psychoneuroses, allergic conditions (pruritus and chronic urticaria)

Question 2

MOA

Answer 2

Hydroxyzine acts to block the action of endogenous histamine at the histamine H1 receptor.

Question 3

Pharmacological effects

Answer 3

antiallergic , antiemetic, anticholinergic ,anxiolytic

Question 4

Pharmacokinetics (way of administration, metabolism, elimination, T1/2)

Answer 4

Oral and IM, metab. By liver, Excr. Urine, T1/2 20 hours

Question 5

Overdose effects

Answer 5

Seizure, QT prolonged, tremor, nausea, vomiting, hypotension, brain damage from lack of oxygen may cause permanent disability

Question 6

Side effects

Answer 6

Chest pain, cough, fainting, dizziness, discomfort,

Question 7

Contraindications for use

Answer 7

Hypersensitivity, cardiovascular diseases, pregnancy

Question 8

Drug interactions

Answer 8

Additive, Hydroxyzine can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.

Question 9

Interactions with products (meal), drinks

Answer 9

Avoid alcohol, may potentiate the CNS adverse effects of hydroxyzine. Co-administration with grapefruit inhibits hydroxyzine metabolism.

Question 10

Children

Answer 10

(itching, anesthetic)
40 kg (2mg) >40kg (100 mg)

Question 11

Elderly patients

Answer 11

A. 50-100mg. elderly patients are more likely to have unwanted side effects (eg, confusion, drowsiness) and age-related liver, kidney, or heart problems

Question 12

Pregnant women

Answer 12

Contraindicated, (Analgesic in labor?)- confuse 1st genera. antihistamine

Question 13

overdose treatment

Answer 13

In case of oral administration, gastric lavage followed by endotracheal intubation.

Activated carbon can be used, but there is insufficient data on its effectiveness. It is necessary to monitor the state of breathing and circulation using ECG monitoring, ensure adequate oxygenation, administer naloxone, dextrose (glucose) and thiamine; if it is necessary to obtain a vasopressor effect, norepinephrine or metaraminol is prescribed; epinephrine should not be used. Cardiac activity and blood pressure should be monitored for 24 hours after symptoms disappear.