Paracetamol

Question 1

MOA of Paracetamol

Answer 1

reversibly inhibits COX 1 and 2 on hypothalamus
COX 1–> decr. thromboxane 2= decr. Platelets
COX 2–> decr. prostaglandin synthesis is CNS= decr. pain and fever

Question 2

Administration of Paracetamol

Answer 2

Orally, rectally or IV

Question 3

Indications of Paracetamol

Answer 3

fever
mild to moderate pain (e.g. myalgia, headache)
Post-operative pain

Question 4

Which drugs can Paracetamol be administered with

Answer 4

Ibuprofen or morphine(severe post-op pain)

Question 5

Paracetamol is 1st line treatment

Answer 5

in kids with fever or pain

Question 6

CI of Paracetamol

Answer 6

Severe hepatic or renal disease

Question 7

DI of Paracetamol

Answer 7

Oral anticoagulants

Question 8

A/E of Paracetamol

Answer 8

Thrombocytopenia(low platelets)
Neutropenia(low WBC)
Hepatotoxicity
Nephrotoxicity

Question 9

PK of Paracetamol
Absorption
Distribution
Metabolism
Half-life
Excretion

Answer 9

A: onset of 1 hr
D: 10-25% protein bound
M: liver via coagulation
T1/2: adults: 2-3hrs
teens-1.25-3hrs
kids: 2-5hrs
Infants: 4hr
Neonates: 7hrs
E: urine

Question 10

Toxicity of Paracetamol leads to

Answer 10

Decr. Glutathione(enzyme that reduces RBC heamolysis)
= Hepatic necrosis and Liver Failure

Question 11

Paracetamol toxicity is treated with

Answer 11

N-Acetylcesteine (NAC)

Question 12

Non-narcotic Analgesics are

Answer 12

aspirin
other salicylates
NSAIDs
Paracetamol
Selective COX 2 inhibitors
DMARDs
TNF inhibitors

Question 13

Narcotic analgesics are

Answer 13

include opiod drugs

Question 14

Narcotic analgesics cause

Answer 14

tolerance and depends
hence why they’re controlled

Question 15

Agents used to treat migrains are

Answer 15

Triptans
B-Blockers
Ca channel blocker
ACEIs and ARBs, Ergot alkaloids