Obesity Flashcards
CIs of drugs used in Obesity
Pregnancy
MOA of Oristal
Pancreatic and gastric-lipase inhibitor
= fat malabsorption that reduces net energy intake
How should Oristal be taken
on a low fat <_ 30% diet to minimize SEs
Where does Oristal act
in stomach and SI
SEs of Oristal
Oily spotting
Flatus with discharge
Fecal urgency
oily evacuation
incr. defection
fecal incontinence
Deficiency in Fat soluble vitamins: A,D,E,K
CIs of Oristal
Pregnancy
Lactation
chronic malabsorption syndrome
Cholestasis
How is Oristal given
Should be given with multivitamins either 2hrs before or after
MOA of Lorcaserin
Selective 5HT2C Receptor agonist
=promotes satiety to reduce food intake
AEs of Lorcaserin in patients without diabetes
headache
dizziness
fatigue
nausea
dry mouth
constipation
AEs of Lorcaserin in patients with diabetes
Hypoglycemia
headache
back pain
fatigue
CI of Lorcaserin
Pregnancy
MOA of Liraglutide
Its a GLP-1 agonist=delays gastric emptying to reduce food intake
AEs of Liraglutide
NV
constipation
diarrhea
Hypogylcaemia
headache
fatigue
dizziness
abd. pain
incr. lipase levels
CI of Liraglutide
Pregnancy
Personal/family history of medullary thyroid cancer
Multiple endocrine neoplasia type 2
MOA of Phenterminetopiramte
Is a NE releasing agent (phentermine), GABA Receptor modulation (topiramate)
=decr. appetite to reduce food intake
SEs of Phenterminetopiramte
Insomnia
dry mouth
constipation
Paresthesias
dizziness
dysgeusia
CIs of Phenterminetopiramte
Pregnancy
Hyperthyroidism
Glaucoma
MAOIs
Hypersensitivity to sympathomimetics
MOA of Naltrexone-bupropion
Opioid antagonist (naltrexone), DA and NE reuptake inhibitor (bupropion)
=acts on CNS pathways to reduce food intake
AEs of Naltrexone-bupropion
NV
constipation
headache
dizziness
insomnia
dry mouth
diarhoea
CIs of Naltrexone-bupropion
Pregnancy
Uncontrolled HTN
seizure disorder
anorexia nervosa or bulimia
drug or alcohol withdrawal
use of MAOIs
long-term opioid use
MOA of Sibutramine (meridia)
NE, DA and Serotonin re-uptake inhibitor
Its an SNRI
AEs of Sibutramine
Incr. HR
Incr. BP
CIs of Sibutramine
Not for patients on SSRIs
Poorly uncontrolled HTN
History of Coronary Artery Disease (CAD)
CHF
Arrythmia
Stroke
