Obesity

Question 1

CIs of drugs used in Obesity

Answer 1

Pregnancy

Question 2

MOA of Oristal

Answer 2

Pancreatic and gastric-lipase inhibitor
= fat malabsorption that reduces net energy intake

Question 3

How should Oristal be taken

Answer 3

on a low fat <_ 30% diet to minimize SEs

Question 4

Where does Oristal act

Answer 4

in stomach and SI

Question 5

SEs of Oristal

Answer 5

Oily spotting
Flatus with discharge
Fecal urgency
oily evacuation
incr. defection
fecal incontinence
Deficiency in Fat soluble vitamins: A,D,E,K

Question 6

CIs of Oristal

Answer 6

Pregnancy
Lactation
chronic malabsorption syndrome
Cholestasis

Question 7

How is Oristal given

Answer 7

Should be given with multivitamins either 2hrs before or after

Question 8

MOA of Lorcaserin

Answer 8

Selective 5HT2C Receptor agonist
=promotes satiety to reduce food intake

Question 9

AEs of Lorcaserin in patients without diabetes

Answer 9

headache
dizziness
fatigue
nausea
dry mouth
constipation

Question 10

AEs of Lorcaserin in patients with diabetes

Answer 10

Hypoglycemia
headache
back pain
fatigue

Question 11

CI of Lorcaserin

Answer 11

Pregnancy

Question 12

MOA of Liraglutide

Answer 12

Its a GLP-1 agonist=delays gastric emptying to reduce food intake

Question 13

AEs of Liraglutide

Answer 13

NV
constipation
diarrhea
Hypogylcaemia
headache
fatigue
dizziness
abd. pain
incr. lipase levels

Question 14

CI of Liraglutide

Answer 14

Pregnancy
Personal/family history of medullary thyroid cancer
Multiple endocrine neoplasia type 2

Question 15

MOA of Phenterminetopiramte

Answer 15

Is a NE releasing agent (phentermine), GABA Receptor modulation (topiramate)
=decr. appetite to reduce food intake

Question 16

SEs of Phenterminetopiramte

Answer 16

Insomnia
dry mouth
constipation
Paresthesias
dizziness
dysgeusia

Question 17

CIs of Phenterminetopiramte

Answer 17

Pregnancy
Hyperthyroidism
Glaucoma
MAOIs
Hypersensitivity to sympathomimetics

Question 18

MOA of Naltrexone-bupropion

Answer 18

Opioid antagonist (naltrexone), DA and NE reuptake inhibitor (bupropion)
=acts on CNS pathways to reduce food intake

Question 19

AEs of Naltrexone-bupropion

Answer 19

NV
constipation
headache
dizziness
insomnia
dry mouth
diarhoea

Question 20

CIs of Naltrexone-bupropion

Answer 20

Pregnancy
Uncontrolled HTN
seizure disorder
anorexia nervosa or bulimia
drug or alcohol withdrawal
use of MAOIs
long-term opioid use

Question 21

MOA of Sibutramine (meridia)

Answer 21

NE, DA and Serotonin re-uptake inhibitor
Its an SNRI

Question 22

AEs of Sibutramine

Answer 22

Incr. HR
Incr. BP

Question 23

CIs of Sibutramine

Answer 23

Not for patients on SSRIs
Poorly uncontrolled HTN
History of Coronary Artery Disease (CAD)
CHF
Arrythmia
Stroke