Androgens

Question 1

Testosterone is produced in

Answer 1

Leydig cells in men
Corpus Luteum and Adrenal cortex in women

Question 2

Function of 5a reductase

Answer 2

converts Testosterone to DIhydrotestosterone and Estradial

Question 3

Uses of Androgens

Answer 3

male hypogonadism
aplastic anemia
Osteoposrosis
Puberty for Testosterone deficient boys
incr. athletic performance: anabolic steroids

Question 4

AEs of Androgens

Answer 4

Excessive masculinization
decr. sperm production
decr. testicular size
Gynecomastia
Virilization in females
Hepatotoxic
Aggressive behavior

Question 5

Effects of Virilisation in females

Answer 5

Hyperandrogenism
Temporal balding
male body physique
muscle building
incr. clitoris size
Hirsutism

Question 6

Admin of Testosterone derivatives

Answer 6

Implant as it undergoes extensive 1st pass metabolism when taken orally=inactivation

Question 7

CIs of Testosterone impkant

Answer 7

Breast, prostate neoplasm

Question 8

Effects of Testosterone implant

Answer 8

May cause premature closing of epiphyses if administered early in puberty
Stimulates endogenous EPO production

Question 9

DIs of Testosterone Implant

Answer 9

Incr. effects of warfarin:=incr. bleeding
May decr blood glycose levels

Question 10

Which are the Testosterone Esters

Answer 10

Testosterone Undecanoate: T deficiency
Enanthate: incr. muscle mass
Cypionate: T. deficiency

Question 11

Uses of Testosterone Esters

Answer 11

improve sexual performance
libido

Question 12

What is Methyltestosterone

Answer 12

17-a-alkyl derivative of T with an oral bioavailability>T.
*its an Ester of T

Question 13

Uses of Methytestosterone

Answer 13

treats men with T. deficiency

Question 14

Cautions with Methytestosterone

Answer 14

Prolonged periods of se
Hepatotoxic

Question 15

What is Mesterolone

Answer 15

dihydroT. derivative that is not metabolised to estrogen
Has an oral bioavailability>T

Question 16

Indications of Mesterolone

Answer 16

Patients with hepatic disease and those woth estrogenic synptoms of other testosterone

Question 17

What is Nandrolone

Answer 17

An anabolic effec with hight anabolic effects and lower androgneic effects

Question 18

Indications of Nandrolone

Answer 18

Treatment of Osteoporosis and Aplastic anemia

Question 19

Effects of Nandrolone

Answer 19

incr. muscle growth
incr. appetite
incr. RBC production
incr. bone density

Question 20

Larger doses of Nandrolone leads to

Answer 20

Gynecomastia
decr. libido

Question 21

AEs of Nandrolone

Answer 21

Erectile dysfunction
CV damage
decr liver hepatic enzymes
liver tumors
cholestatic jaundice

Question 22

Name an Antigonadotropin

Answer 22

Danazol

Question 23

MOA of Danazol

Answer 23

binds to estrogen Rs–> inhibits Gonadotropin secretion

Question 24

Activities of danazol

Answer 24

Weak pregestational, androgenic and glucocorticoid activities

Question 25

Danazol induces

Answer 25

Endometrial atrophy

Question 26

AEs of Danazol

Answer 26

greasy skin acne voice changes weight gain

Question 27

Clinical uses of Danazol

Answer 27

For Sex hormone dependent conditions: Endometriosis Breast dysplasia Gynecomastia

Question 28

What are Antiandrogens

Answer 28

are inhibitors of Testosterone synthesis

Question 29

MOA of Antiandrogens

Answer 29

GNRH analogues that inhibit LH secretion thus they inhibit Testosterone synthesis

Question 30

Name the Antiandrogens

Answer 30

Flutamide Spironolactone Cyproterone acetate Goserelin Leuprorelin Triptorelin Buserelin

Question 31

What is Flutamide

Answer 31

potent androgen receptor antagonists

Question 32

Indications of Flutamide

Answer 32

treats metastatic cancer: GnRH analogue blocks action of adrenal glands

Question 33

AEs of Fluatmide

Answer 33

Gynecomastia Galactorrhea NV decr. libido Hepatotoxic

Question 34

What is Spironoloactone

Answer 34

Weak inhibitor of Androgen Rs thus weak testosterone inhibition Aldosterone inhibitor Competitive inhibitor of DHT at target organs

Question 35

Indications of Spironolactone

Answer 35

Hirsutism in females

Question 36

What is Cyproterone Acetate

Answer 36

its a competitve agonist to DHT is a progestin has antiandrogenic properties

Question 37

Indications of Cyproterone Acetate

Answer 37

Hirsutism Severe acne

Question 38

AEs of Cyproterone Acetate

Answer 38

weight gain decr. libido dry vagina

Question 39

CIs of Cyproterone Acetate

Answer 39

Pregnancy: teratogenic

Question 40

What is Finasteride

Answer 40

A 5a-reductase inhibitor --> blocks conversion of Testosterone to DHT (reversible within 4 months of therapy)

Question 41

Indications of Finasteride

Answer 41

Treatment of BPH: shrinkage of prostate gland in 3-6monthes Male pattern baldness hisutism

Question 42

AEs of Finasteride

Answer 42

infrequently causes impotence RARE: decr libido, gynecomastia, erectile dysfunction, decr. ejaculation

Question 43

Pulsatile admin of GnRH analogues cause

Answer 43

incr. circulating gonadotropines--> treats infertility

Question 44

Sustained admin of GnRH analogues cause

Answer 44

reduction in steroid secretion--> treatment of hormone dependent cancer

Question 45

Indications of Goserelin

Answer 45

Breast and prostate cancer Dysfunctional uterine bleeding

Question 46

AEs of Goserelin

Answer 46

Headache depression hot flushes vaginal dryness

Question 47

Indications of Leuprorelin

Answer 47

advanced and metastatic prostate cancer Endometriosis Infertility

Question 48

AEs of Leuprorelin

Answer 48

Ovarian hyperstimulation headache mood disorders visual disturbances

Question 49

Indications of Triptorelin

Answer 49

Advanced prostate cancer Central precocious Puberty Endometriosis Infertility

Question 50

AEs of Triptorelin

Answer 50

Ovarian hyperstimulation headache mood disorders visual disturbances

Question 51

Indications of Buserelin

Answer 51

Decr. Testosterone production Advanced and metastatic prostate cancer Endometriosis Infertility

Question 52

AEs of Buserelin

Answer 52

hot flushes loss of libido