Papillomaviridae

Question 1

What type of genome does Papillomaviridae have?

Answer 1

circular dsDNA
non enveloped
icosohedral

Question 2

What is the virus affecting dogs in the Papillomaviridae family?

Answer 2

Papillomavirus

Question 3

what tissues does the canine papillomavirus target?

Answer 3

Skin, lip and mucous membrane warts – genitals, respiratory tract also
squamous epithelium

Question 4

what is the only age group that is susceptible to CPV?

Answer 4

Young dogs < 1 year

Older dogs, even if unvaccinated will not get it

Question 5

What is the progression of COPV?

Answer 5

small, smooth papular elevation on lip –> buccal mucosa, tongue, hard palate and walls of pharynx –> irregular surface (cauliflower shape is typical) –> Hyperplasia of keratin seen first, virus is not detected yet –> virus stimulates mitosis of cell proliferation

Question 6

Where can you see viral aggregates of COPV?

Answer 6

Stratum granulosum and upper part of stratum spinosum of degenerated cells
cytoplasmic and nuclear inclusions!

Question 7

T/F

Intramuscular and subcutaneous introduction of CPV will cause immediate infection

Answer 7

False

IM or SQ exposure will not transmit –> induces immunity!

Question 8

How is CPV transmitted?

Answer 8

rubbing pieces or filtrates of tumor tissues onto scarified oral mucosa
close contact

Question 9

Is there a vaccine available for CPV?

Answer 9

Yes – not recommended unless there is high incidence of papillomas in a kennel
Inactive virus vaccines available