Adenoviridae

Question 1

What kind of DNA does an adenovirus have?

Answer 1

dsDNA
icosahedral nucleocapsid
no envelope

Question 2

What is unique about adenoviridae composition?

Answer 2

Only virus with fiber protruding from each of the 12 pentons

Fiber = structure of attachment to host cells + type of specific hemagglutinin

Question 3

What is the virus that causes infectious canine hepatitis? also known as?

Answer 3

Mastadenovirus

Canine adenovirus -1 (CAV-1)

Question 4

Can adenovirus hemagglutinate the host RBC?

Answer 4

Yes

Question 5

How is CAV-1 different from CAV-2 in clinical presentation?

Answer 5

CAV-2 causes respiratory infection

CAV-1 – hepatitis

Question 6

How is CAV-1 transmitted?

Answer 6

Oronasal route
contact, fomites, ectoparasites
body tissues and secretions of infected dogs
Urine (6-9 months) after recovery

Question 7

What age group is more susceptible to CAV-1?

Answer 7

dogs less than 1 year old

Question 8

What tissue is prime target for CAV-1 replication?

Answer 8

Liver parenchyma

Vascular endothelium

Question 9

What are some major clinical signs of canine hepatitis?

Answer 9

Fever
coughing
pneumonia
subcutaneous edema
epistaxis
eye infection
CNS signs

Question 10

Is there a vaccine available for CAV?

Answer 10

yes

modified live for CAV-1 and CAV-2

Question 11

How do you diagnose CAV?

Answer 11

Clinical signs and pathology
*intranuclear inclusion bodies
virus isolation
*ELISA
IFA
*PCR

Question 12

What major organs are affected by canine adenovirus?

Answer 12

Liver
Kidney
Eye
Vessel endothelium

Question 13

What is blue eye with CAV?

Answer 13

corneal edema from uveitis

may be from Ag-Ab immunocomplex in eye