Circoviridae

Question 1

Does PCV-1 or PCV-2 cause clinical infection?

Answer 1

PCV-2

Question 2

How is porcine multisystemic wasting syndrome develop?

Answer 2

Stress

infection with ther agent (PCV-1, porcine parvovirus, or PRRS)

Question 3

What is route of transmission for PCV-2?

Answer 3

oronasal

Question 4

Are there vaccines available for PCV? Be specific

Answer 4

Yes

inactivated is available to aid in prevention of PMWS

Question 5

T/F

circoviruses have hemagglutination abilities

Answer 5

False

Question 6

Does the PCV-2 show inclusion bodies?

Answer 6

Yes – in macrophages

Question 7

What organs do we look at for PMWS?

Answer 7

Lymphatic
Lung
Liver
Kidney

Question 8

What age group does the PMWS appear in?

Answer 8

6 week old piglets

Question 9

What age should piglets be vaccinated to avoid PMWS?

Answer 9

4 weeks

Question 10

What is common presentation of piglets with PMWS?

Answer 10

Progressive weight loss
dyspnea
icterus (hepatitis)
Lymphadenomegaly

Question 11

What are target cells for PCV-2 replication?

Answer 11

macrophages
B and T lymphocytes
hepatocytes
respiratory and intestinal epithelial cells

Question 12

What type of congenital tremors is caused by a circovirus?

Answer 12

Type A-II

Question 13

What pigs are affected by porcine dermatitis and nephropathy syndrome and how does PDNS present?

Answer 13

weaners and growing-finishing pigs
skin lesions of orund to irregular shape, red to purple macules and papules.
Crusts may develop

Question 14

What circovirus disease can cause sudden death?

Answer 14

Porcine dermatitis and nephropathy syndrome

Question 15

T/F

Porcine dermatitis and nephropathy syndrome is an immune-complex mediated disease

Answer 15

True

Question 16

Is circovirus a DNA or RNA virus. Be specific

Answer 16

small circular ssDNA
non-enveloped
icosahedral

Question 17

What three diseases are commonly associated with PCV-2?

Answer 17

1. Porcine/postweaning systemic wasting syndrome (PMWS)
2. Congenital tremors
3. Porcine dermatitis and nephropathy syndrome (PDNS)

Question 18

How can we limit transmission of PCV?

Answer 18

good husbandry
Solid walls
cleaning and disinfecting

Question 19

What are some diagnostic measures you can take to diagnose PCV-2?

Answer 19

Clinical signs
Histopathology
IFA
Immunohistochemistry
PCR
ELISA