Circoviridae Flashcards
Does PCV-1 or PCV-2 cause clinical infection?
PCV-2
How is porcine multisystemic wasting syndrome develop?
Stress
infection with ther agent (PCV-1, porcine parvovirus, or PRRS)
What is route of transmission for PCV-2?
oronasal
Are there vaccines available for PCV? Be specific
Yes
inactivated is available to aid in prevention of PMWS
T/F
circoviruses have hemagglutination abilities
False
Does the PCV-2 show inclusion bodies?
Yes – in macrophages
What organs do we look at for PMWS?
Lymphatic
Lung
Liver
Kidney
What age group does the PMWS appear in?
6 week old piglets
What age should piglets be vaccinated to avoid PMWS?
4 weeks
What is common presentation of piglets with PMWS?
Progressive weight loss
dyspnea
icterus (hepatitis)
Lymphadenomegaly
What are target cells for PCV-2 replication?
macrophages
B and T lymphocytes
hepatocytes
respiratory and intestinal epithelial cells
What type of congenital tremors is caused by a circovirus?
Type A-II
What pigs are affected by porcine dermatitis and nephropathy syndrome and how does PDNS present?
weaners and growing-finishing pigs
skin lesions of orund to irregular shape, red to purple macules and papules.
Crusts may develop
What circovirus disease can cause sudden death?
Porcine dermatitis and nephropathy syndrome
T/F
Porcine dermatitis and nephropathy syndrome is an immune-complex mediated disease
True
Is circovirus a DNA or RNA virus. Be specific
small circular ssDNA
non-enveloped
icosahedral
What three diseases are commonly associated with PCV-2?
- Porcine/postweaning systemic wasting syndrome (PMWS)
- Congenital tremors
- Porcine dermatitis and nephropathy syndrome (PDNS)
How can we limit transmission of PCV?
good husbandry
Solid walls
cleaning and disinfecting
What are some diagnostic measures you can take to diagnose PCV-2?
Clinical signs Histopathology IFA Immunohistochemistry PCR ELISA
