Pantothenic Acid Flashcards

1
Q

Describe Pantothenic Acid structure

A

beta-alanine and Pantoic acid, does not contain sulfur

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2
Q

what does Pantothenic acid create

A

CoA

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3
Q

Step 1 of Pantothenic to CoA

A

uses 1 ATP–> removal of side group of acid

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4
Q

Step 2 of Pantothenic Acid to CoA

A

1 ATP–> addition of phosphate

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5
Q

step 3 Pantothenic to CoA

A

release of CO2–> addition of reactive site on b-alanine side

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6
Q

step 4 of Pantothenic acid to CoA

A

2 ATP–> removal of carboxyl group within the reactive site

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7
Q

Food sources

A

present in all plant and animal foods

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8
Q
A
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9
Q

how is Pantothenic acid usually found

A

as CoA component

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10
Q

Explain the digestion

A

CoA is too large to digest so it is hydrolyzed to pantothenic acid

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11
Q

Absorption of B5

A

passive diffusion in jejunum

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12
Q

what is the bioavailability of B5

A

50%, decreases with supplements

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13
Q

where does most CoA occur

A

red blood cells

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14
Q

uptake of B5

A

sodium dependent within muscles and liver; facilitated within CNS, adipose, kidneys

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15
Q

Function within cells

A

synthesize CoA

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16
Q

How many ATPs can be created with 1 CoA

A

12

17
Q

Functions

A

needed for glycolysis and TCA, beta oxidation of fatty acids, synthesis of fatty acids

18
Q

Synthesis of Fatty Acids

A

Acetyl CoA cannot leave the mitochondria; OAA + Acetyl CoA–> Citrate +CoA used to leave mitochondria then reverse; FA synthesis may occur

19
Q

Acetylation of proteins

A

donation of LCFA to proteins; may protect from degradation

20
Q

Excretion

A

CoA is converted to pantothenate then excreted in urine

21
Q

DRI/AI

A

5 mg/d

22
Q

deficiency

A

Burning Feet syndrome, reported in people with severe malnutrition

23
Q

Toxicity

A

not reported; may increase niacinn excretion

24
Q

Assessment

A

Plasma pantothenic acid concentrations