Pandemic Flu Flashcards
1
Q
Peaks at beginning of January
A
Influenza A H1
2
Q
Peaks end of December
A
Influenza A (H1N1)
3
Q
Peaks March
A
Influenza B
4
Q
Number of RNA segments
A
8
Nucleocapsid protein prone to mutation
5
Q
Cleaves sialic acid residues exposing receptors on host cell disrupting mucin barrier
A
Neuraminidase (sialidase) activity
6
Q
Bind sialic acid receptors, virus entry. Endosomal-viral envelope fusion - release
A
Haemogglutinin activity
7
Q
Mutation occur HA/NA to give new strains
A
Antigenic drift
8
Q
Complete change of HA/NA
A
Antigenic Shift
Only Influenza A
Trading of RNA between human and animal strains
9
Q
Antivirals
A
Amantidine (Influenza A) single AA mutation = resistance
Neuraminidase inhibitors - effective only if given within 48 hours
