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Microbiology > Fever > Flashcards

Fever Flashcards

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Biology 101 flashcards
1
Q

Epitheliotropic virus in which infected cells swell

Often a latent infection

A

CMV

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2
Q

Percentage of CMV which is asymptomatic

A

80%

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3
Q

Congenital CMV

A 
IUGR
Jaundice
Hepatoslenomegaly
Chorioretinitis
Encephalitis - microcephaly, thrombocytopenia, death
Late progressive sensorineural deafness
Impaired IQ
Cytomegalice inclusion disease - 13%
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4
Q

CMV mononucleosis

A

Similar to EBV

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5
Q

Immuno-compromised CMV infection

A 
Fever
Hepatitis
GI - colitis, retinitis, pneumonitis, bone marrow suppression, addisons disease, radiculopathy
Pneumonitis - BMT patients
Retinitis - AIDS
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6
Q

Cells that caln be infected by CMV

A

Macrophages
Endothelial cells
B and T lymphocytes
BOne marrow stem cells

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7
Q

Diagnosis of CMV

A

BLood PCR
Histopathology
Tissue immunofluorescence
Cell culture in human fibroblasts
Owl’s eye inclusions
Serology
Immunocompetent - serology CMV IgM and IgG (IgG low avidity in priamry infecton)
Immunocompromised - Serology - limited diagnostic value
Heterophile’s Ab’s - Paul Bunnel/monospot - clumping of sheep RBCs

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8
Q

Treatment of CMV

A

Gancivlovir (valganciclovir - prodrug), Cidofovir, Foscarnet

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9
Q

Roseola virus

A

Roseola infantum (exanthum subitum, Sixth disease)
3 days fever, then transient rash
Abx prescribed for fever - rash blamed on penicillin allergy
Most common cause of febrile convulsions
Latent in mono/lymphocytes
Can cause pneumonitis, hepatitis, encephalitis in BMT
Diagnosis - BLood PCR
Rx - Ganciclovir, foscarnet or cidofivir

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10
Q

Infectious mononucleosis - Triad

A 
EBV
Fever
Pharyngitis
Lymphadenopathy
Incubation - 4-6 weeks
Maculopapular rash
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11
Q

Diagnosis of Infectious mononucleosis

A

BLood film
Monospot agglutination
EBV antibodies
Paul-Bunnell test

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12
Q

African kids with a big jaw

A

Burkitt’s Lymphoma

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13
Q

Nasopharyngeal cancer

A

EBV
Genital
Kissing disease

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14
Q

Post-transplant lymphoproliferative disease

A

Predisposes to lymphoma
Treatment - reduce immunosuppression + give rituximab (anti-CD20 monoclonal Ab)

EBV is not dangerous in pregnancy

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15
Q

HHV-8

A 
Genitally transmitted
ASsociated with Kaposi's sarcoma
PRimary effusion lymphoma
Castleman's disease (non-cancerous growth in LNs)
Rx - Ganciclovir and FOscarnet
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Microbiology (27 decks)

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