Pancytopenia + BM failure Flashcards
1
Q
What are causes of pancytopenia?
A
- ↓ marrow production:
- aplastic anaemia
- infiltration e.g. acute leukaemia, myelodysplasia, myeloma, lymphoma, megaloblastic anaemia, myelofibrosis - ↑ peripheral destruction - hypersplenism
2
Q
What are granulocytes
A
wbcs w neutrophil, basophil or eosinophil granules
3
Q
What is the risk of agranulocytosis
A
fatal infections
4
Q
What drugs can cause agranulocytosis
A
Carbimazole (hyperthyroidism)
Procainamide (antiarrhythmic)
Sulfonamides
Clozapine (atypical antipsychotic)
5
Q
How much should 1U of a red cell transfusion raise the Hb by?
A
10-15g/L
6
Q
When are platelets indicated?
A
platelet levels <10
haemorrhage
before invasive procedures to ↑ count to >50
7
Q
How long do platelets survive for?
A
8 days
8
Q
How long do neutrophils survive for?
A
1-2 days
