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Y3 Haematology > Pancytopeania > Flashcards

Pancytopeania Flashcards

1
Q

Define pancytopeania

A

Deficiency of all blood cell lineages; low platelets, low red cells, low white cells

(Doesn’t really include lymphocytes)

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2
Q

Pancytopeania is always associated with marrow failure. T or F

A

False

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3
Q

Inherited marrow failure syndromes are all associated with an increased risk of ……

A

cancer

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4
Q

Name the inherited marrow failure syndrome we were taught?

A

Fanconi’s anaemia

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5
Q

Fanconi’s anaemia:

  • presents in what age range
  • hypo or hyperpigmentation
  • what skeletal abnormalitity
  • first detectable blood abnormality
A

Children
Hyperpigmentation
Absent thumbs / radius
Macrocytosis

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6
Q

What is the pathology behind aplastic anaemia?

A

Autoimmune T cell against haematopoietic stem cell

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7
Q

Is aplastic anaemia hyper, normo or hypo-cellular?

A

Hypocellular

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8
Q

Is the myeloid or lymphoid lineage effected by aplastic anaemia?

A

Myeloid

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9
Q

Myelodysplasia is a precursor to what?

A

AML

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10
Q

What age range does myelodysplasia occur in?

A

Elderly

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11
Q

Is myelodysplasia hyper, normo or hypo-cellular?

A

Hypercellular

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12
Q

Are blasts found in myelodysplasia?

A

Yes but less than 20%

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13
Q

What tests are done for myelodysplasia?

A

Blood count
Blood film
Marrow biopsy

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14
Q

Name 5 secondary causes of marrow failure?

A 
Drugs
HIV
Met
B12/folate
Stroage disease
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15
Q

Name 3 drugs that can cause a secondary marrow failure

A

Allopurinol
Chloramphenicol
Methotrexate

(Also alcohol)

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16
Q

Is drug induced pancytopeania hyper, normo or hypo-cellular?

A

Hypocellular

17
Q

Is HIV induced pancytopeania hyper, normo or hypo-cellular?

A

Hypocellular

18
Q

Is B12/folate induced pancytopeania hyper, normo or hypo-cellular?

A

Hypercellular

19
Q

Pathology of what organ in the abdominal cavity can cause pancytopenia?

A

Hypersplenism

20
Q

Is hypersplenism induced pancytopeania hyper, normo or hypo-cellular?

A

Hypercellular

21
Q

In hypersplenism is the transit time in the spleen increased or decreased? Are the more or less cells than usual in the spleen?

A

Slower transit time - means more cell destroyed whilst

More cells than usual in spleen - less in circulation

22
Q

Portal HTN, CHF and Felty’s syndrome all have what complication?

A

Hypersplenism

23
Q

Is a marrow biopsy always indicated when investigating pancytopeania?

A

Yes

DOUBLE CHECK THIS

24
Q

What is the treatment of inherited marrow failure syndromes?

A

Supportive

Marrow transplant

25
Q

What is the management of aplastic anaemia?

A

Immunosuppress

Y3 Haematology (15 decks)

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