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Physiology Exam V > Pancreas > Flashcards

Pancreas Flashcards

1
Q

What are 3 key cell types that are improtant to exocrine fucntion of pancreas

A

acinar, duct, goblet

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2
Q

function of acinar cell

A

protein synthesizing cells

secrete digestive enzyme and fluid

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3
Q

functino of duct cell

A

secretes bicarb

helps with ion and water transport

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4
Q

function of goblet cell

A

secrete mucin

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5
Q

What are 2 primary stimuli for fluid and enzyme secretion by pancreatic acinar cells

A

CCK

Ach

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6
Q

function of CCK

A

promote fluid and enzyme secretion
promote through Ca++ signaling docking and vesicular release
will give neg feedback after there is enough fluid/enzymes

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7
Q

what do CCK and Ach both do

A

promote vesicle fusion, regulate Cl- ion channel

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8
Q

how are zymogens stores in pancrea

A

in vesicles with trypsin inhibitor. low pH of vesicle prevents enzyme activation

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9
Q

how are symogens activated in duodenum

A

entereopeptidase is secreted which converts trypsinogen to trypsin

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10
Q

What is the primary stimulus for secretion of bicarbonate from pancreatic duct cells

A

secretin

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11
Q

function of secretion

A

protect duodenal epithelium from acid by secreting bicarb

gives neg feedback to stomach

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12
Q

what are the 3 phases of pancreatic seceretion

A

cephalic, gastric, intestinal

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13
Q

how is the cephalic phase stimulated

A

sight, smell, taste, masticulation

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14
Q

how is the gastric phase stimulated

A

distension, gastrin, peptides/peptone

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15
Q

how is the intestinal phase stimulated

A

amino acids
fatty acids
H+

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16
Q

how is cephalic phase regulated

A

vagal pathway

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17
Q

how is gastric phase regulated

A

vagal/gastrin pwathway

18
Q

how is intestinal phase reulgated

A

CCK, secretion, enteropancreatic reflex

19
Q

what is the stimulus for returning the levels of pancreatic secretion from the fed state to interdigestive state

A

release of peptide YY and somatostatin

20
Q

how does blood move through the liver

A

form portal vein to central vein

21
Q

how does bile move through the liver

A

from the central vein to the portal vein

22
Q

uptake in liver

A

freely diffused across the basolateral membrane

facilitated by FCTP

23
Q

transport in liver

A

intracellular movements can be directed by binding more

24
Q

biotransofrmation phase I

A

expsoe a functional group

25
Q

biotransprotion phase II

A

making it more water soluble, and larger

26
Q

secretion

A

secretion of produces across apical or basolateral membrane

27
Q

what goes into blood

A

more water soluble

28
Q

what goes into bile

A

less water soluble

29
Q

bile salt biosynthetic pathway

A

cholesterol to bile acid to bile salt

30
Q

what transforms secondary bile acids

A

gut bacteria

31
Q

what secretes bile salts

A

liver

32
Q

what inhibits secretion of bile into duodenum

A

somatostatine

33
Q

what promotes secretion of bile into duodenum

A

CCK

34
Q

what is enterohepatic cirucalation

A

recycling of bile

35
Q

pancreastitis

A

inflammation of pancreas

decreases secretion of digestive enzymes which causes malaboprtion of dietary nutrients

36
Q

portal hypertension

A

high blood pressure in protal venous system

leads to varices, splenomegaly, ascities and hepatic encephalopthy

37
Q

jaudice

A

yellowing of skin due to elevated bilirubin

impaired bile excretion from liver

38
Q

cirrhosis

A

fibrosis of hepatic tissue resulting in altered hepatic blood flow and function
causes portal hypertension, jaundice

39
Q

cholestasis

A

impaired bile flow

caused by choleslithiasis and cholescysitis

40
Q

cholithaisis

A

gallstone formation

overproduction of cholesterol or impaired production of bile salts

41
Q

cholecystitis

A

inflammation of gallbladder

can be caused by stones lodged in cystic duct

Physiology Exam V (14 decks)

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